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The effects of grow...
The effects of growing up on a farm on adult lung function and allergic phenotypes : an international population-based study
- Article/chapterEnglish2017
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2016-09-26
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BMJ,2017
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-311302
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311302URI
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https://doi.org/10.1136/thoraxjnl-2015-208154DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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RATIONALE: Evidence has suggested that exposure to environmental or microbial biodiversity in early life may impact subsequent lung function and allergic disease risk.OBJECTIVES: To investigate the influence of childhood living environment and biodiversity indicators on atopy, asthma and lung function in adulthood.METHODS AND MEASUREMENTS: The European Community Respiratory Health Survey II investigated ∼10 201 participants aged 26-54 years from 14 countries, including participants' place of upbringing (farm, rural environment or inner city) before age 5 years. A 'biodiversity score' was created based on childhood exposure to cats, dogs, day care, bedroom sharing and older siblings. Associations with lung function, bronchial hyper-responsiveness (BHR), allergic sensitisation, asthma and rhinitis were analysed.MAIN RESULTS: As compared with a city upbringing, those with early-life farm exposure had less atopic sensitisation (adjusted OR 0.46, 95% CI 0.37 to 0.58), atopic BHR (0.54 (0.35 to 0.83)), atopic asthma (0.47 (0.28 to 0.81)) and atopic rhinitis (0.43 (0.32 to 0.57)), but not non-atopic outcomes. Less pronounced protective effects were observed for rural environment exposures. Women with a farm upbringing had higher FEV1 (adjusted difference 110 mL (64 to 157)), independent of sensitisation and asthma. In an inner city environment, a higher biodiversity score was related to less allergic sensitisation.CONCLUSIONS: This is the first study to report beneficial effects of growing up on a farm on adult FEV1. Our study confirmed the beneficial effects of early farm life on sensitisation, asthma and rhinitis, and found a similar association for BHR. In persons with an urban upbringing, a higher biodiversity score predicted less allergic sensitisation, but to a lesser magnitude than a childhood farm environment.
Subject headings and genre
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Raherison, C
(author)
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Lodge, C J
(author)
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Lowe, A J
(author)
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Gislason, T
(author)
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Heinrich, J
(author)
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Sunyer, J
(author)
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Gómez Real, F
(author)
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Norbäck, DanUppsala universitet,Arbets- och miljömedicin(Swepub:uu)dagnorba
(author)
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Matheson, M C
(author)
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Wjst, M
(author)
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Dratva, J
(author)
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de Marco, R
(author)
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Jarvis, D
(author)
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Schlünssen, V
(author)
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Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn
(author)
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Leynaert, B
(author)
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Svanes, C
(author)
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Dharmage, S C
(author)
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Uppsala universitetArbets- och miljömedicin
(creator_code:org_t)
Related titles
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In:Thorax: BMJ72:3, s. 236-2440040-63761468-3296
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Thorax
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Campbell, B
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Raherison, C
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Lodge, C J
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Lowe, A J
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Gislason, T
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Heinrich, J
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Sunyer, J
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Gómez Real, F
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Norbäck, Dan
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Matheson, M C
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Wjst, M
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Dratva, J
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de Marco, R
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Jarvis, D
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Schlünssen, V
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Janson, Christer
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Leynaert, B
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Svanes, C
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Dharmage, S C
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- MEDICAL AND HEALTH SCIENCES
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and Respiratory Medi ...
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- MEDICAL AND HEALTH SCIENCES
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Thorax
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Uppsala University