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Zoanthamine-Type Al...
Zoanthamine-Type Alkaloids from the Zoanthid Zoanthus kuroshio Collected in Taiwan and Their Effects on Inflammation
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- Hsu, Yu-Ming (author)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.
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- Chang, Fang-Rong (author)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ, Ctr Infect Dis & Canc Res, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 80708, Taiwan.;Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan.;Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung 80708, Taiwan.
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- Lo, I-Wen (author)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.
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- Lai, Kuei-Hung (author)
- Uppsala universitet,Avdelningen för farmakognosi,Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.
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- El-Shazly, Mohamed (author)
- Ain Shams Univ, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Cairo 11566, Egypt.
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- Wu, Tung-Ying (author)
- China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan. China Med Univ Hosp, Ctr Mol Med, Taichung 40402, Taiwan.
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- Du, Ying-Chi (author)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.
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- Hwang, Tsong-Long (author)
- Chang Gung Univ Sci & Technol, Res Ctr Chinese Herbal Med, Res Ctr Ind Human Ecol, Taoyuan 33302, Taiwan.;Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 33302, Taiwan. China Med Univ, Sch Pharm, Coll Pharm, Taichung 40402, Taiwan. China Med Univ, Res Ctr Chinese Herbal Med, Taichung 40402, Taiwan.
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- Cheng, Yuan-Bin (author)
- Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ, Ctr Infect Dis & Canc Res, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 80708, Taiwan.
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- Wu, Yang-Chang (author)
- Uppsala universitet,Avdelningen för farmakognosi,Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;Ain Shams Univ, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Cairo 11566, Egypt.;China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan. China Med Univ Hosp, Ctr Mol Med, Taichung 40402, Taiwan.;Chang Gung Univ, Grad Inst Nat Prod, Coll Med, Taoyuan 33302, Taiwan.
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Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ, Ctr Infect Dis & Canc Res, Kaohsiung 80708, Taiwan.;Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 80708, Taiwan.;Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan.;Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung 80708, Taiwan. (creator_code:org_t)
- 2016-10-19
- 2016
- English.
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In: Journal of natural products (Print). - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 79:10, s. 2674-2680
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Zoanthus kuroshio is a colorful zoanthid with a fluorescent pink oral disc and brown tentacles, which dominates certain parts of the Taiwanese and Japanese coasts. This sea anemone is a rich source of biologically active alkaloids. In the current investigation, two novel halogenated zoanthamines [5 alpha-iodozoanthenamine (1) and 11 beta-chloro-11-deoxykuroshine A (2)], along with four new zoanthamines [18-epi-kuroshine A (3), 7 alpha-hydroxykuroshine E (4), 5 alpha-methoxykuroshine E (5), and 18-epi-kuroshine E (6)], and six known compounds were isolated from Z. kuroshio. Compounds 1 and 2 are the first examples of halogenated zoanthamine-type alkaloids isolated from nature. Compounds 3 and 6 are the first zoanthamine stereoisomers with a cis-junction of the A/B rings. All isolated compounds were evaluated for their anti-inflammatory activities by measuring their effects on superoxide anion generation and elastase release by human neutrophils in response to fMLP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hsu, Yu-Ming
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Chang, Fang-Rong
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Lo, I-Wen
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Lai, Kuei-Hung
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El-Shazly, Moham ...
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Wu, Tung-Ying
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show more...
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Du, Ying-Chi
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Hwang, Tsong-Lon ...
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Cheng, Yuan-Bin
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Wu, Yang-Chang
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
- Articles in the publication
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Journal of natur ...
- By the university
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Uppsala University