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Risk factors for pr...
Risk factors for progression in children and young adults with IgA nephropathy : an analysis of 261 cases from the VALIGA European cohort
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- Coppo, Rosanna (author)
- Regina Margherita Hosp, Fdn Ric Molinette Nephrol Dialysis & Transplantat, Turin, Italy.
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- Lofaro, Danilo (author)
- Annunziata Hosp, Cosenza, Italy.
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- Camilla, Roberta R. (author)
- Regina Margherita Hosp, Fdn Ric Molinette Nephrol Dialysis & Transplantat, Turin, Italy.
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- Bellur, Shubha (author)
- Oxford Univ Hosp, Oxford, England.
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- Cattran, Daniel (author)
- Toronto Gen Hosp, Univ Hlth Network, Toronto, ON, Canada.
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- Cook, H. Terence (author)
- Imperial Coll, Hammersmith Hosp, London, England.
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- Roberts, Ian S. D. (author)
- Oxford Univ Hosp, Oxford, England.
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- Peruzzi, Licia (author)
- Regina Margherita Hosp, Fdn Ric Molinette Nephrol Dialysis & Transplantat, Turin, Italy.
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- Amore, Alessandro (author)
- Regina Margherita Hosp, Fdn Ric Molinette Nephrol Dialysis & Transplantat, Turin, Italy.
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- Emma, Francesco (author)
- Bambino Gesu Pediat Hosp, Rome, Italy.
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- Fuiano, Laura (author)
- Bambino Gesu Pediat Hosp, Rome, Italy.
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- Berg, Ulla (author)
- Karolinska Institutet
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- Topaloglu, Rezan (author)
- Hacettepe Univ, Ankara, Turkey.
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- Bilginer, Yelda. (author)
- Hacettepe Univ, Ankara, Turkey.
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- Gesualdo, Loreto (author)
- Univ Bari & Foggia, Bari, Italy.
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- Polci, Rosaria (author)
- Belcolle Hosp, Viterbo, Italy.
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- Mizerska-Wasiak, Malgorzata (author)
- Univ Warsaw, Warsaw, Poland.
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- Caliskan, Yasar (author)
- Istanbul Univ, Istanbul, Turkey.
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- Lundberg, Sigrid (author)
- Karolinska Institutet
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- Cancarini, Giovanni (author)
- Spedali Civili Univ Hosp, Brescia, Italy.
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- Geddes, Colin (author)
- Western Infirm Glasgow, Glasgow, Lanark, Scotland.
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- Wetzels, Jack (author)
- Radboud Univ Nijmegen, Nijmegen, Netherlands.
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- Wiecek, Andrzej (author)
- Silesian Univ, Katowice, Poland.
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- Durlik, Magdalena (author)
- Med Univ Warsaw, Warsaw, Poland.
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- Cusinato, Stefano (author)
- Borgomanero Hosp, Borgomanero, Italy.
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- Rollino, Cristiana (author)
- San Giovanni Bosco Hosp, Turin, Italy.
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- Maggio, Milena (author)
- Hosp Maggiore Lodi, Lodi, Italy.
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- Praga, Manuel (author)
- Hosp 12 Octubre, Madrid, Spain.
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- Smerud, Hilde Kloster (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Tesar, Vladimir (author)
- Gen Univ Hosp, Prague, Czech Republic.
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- Maixnerova, Dita (author)
- Gen Univ Hosp, Prague, Czech Republic.
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- Barratt, Jonathan (author)
- Leicester Gen Hosp, Leicester, Leics, England.
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- Papalia, Teresa (author)
- Annunziata Hosp, Cosenza, Italy.
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- Bonofiglio, Renzo (author)
- Annunziata Hosp, Cosenza, Italy.
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- Mazzucco, Gianna (author)
- Univ Turin, Turin, Italy.
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- Giannakakis, Costantinos (author)
- Univ Rome, Rome, Italy.
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- Söderberg, Magnus (author)
- Karolinska Univ Hosp, Huddinge, Sweden.
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- Orhan, Diclehan (author)
- Hacettepe Univ, Ankara, Turkey.
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- Di Palma, Anna Maria (author)
- Univ Bari & Foggia, Bari, Italy.
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- Maldyk, Jadwiga (author)
- Univ Warsaw, Warsaw, Poland.
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- Ozluk, Yasemin (author)
- Istanbul Univ, Istanbul, Turkey.
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- Sudelin, Birgitta (author)
- Karolinska Inst, Stockholm, Sweden.
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- Tardanico, Regina (author)
- Spedali Civili Univ Hosp, Brescia, Italy.
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- Kipgen, David (author)
- Western Infirm Glasgow, Glasgow, Lanark, Scotland.
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- Steenbergen, Eric (author)
- Radboud Univ Nijmegen, Nijmegen, Netherlands.
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- Karkoszka, Henryk (author)
- Silesian Univ, Katowice, Poland.
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- Perkowska-Ptasinska, Agnieszka (author)
- Med Univ Warsaw, Warsaw, Poland.
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- Ferrario, Franco (author)
- Monza Hosp, Monza, Italy.
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- Gutierrez, Eduardo (author)
- Hosp 12 Octubre, Madrid, Spain.
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- Honsova, Eva (author)
- Gen Univ Hosp, Prague, Czech Republic.
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Regina Margherita Hosp, Fdn Ric Molinette Nephrol Dialysis & Transplantat, Turin, Italy Annunziata Hosp, Cosenza, Italy. (creator_code:org_t)
- 2016-08-25
- 2017
- English.
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In: Pediatric nephrology (Berlin, West). - : Springer Science and Business Media LLC. - 0931-041X .- 1432-198X. ; 32:1, s. 139-150
- Related links:
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https://urn.kb.se/re...
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Abstract
Subject headings
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- There is a need for early identification of children with immunoglobulin A nephropathy (IgAN) at risk of progression of kidney disease. Data on 261 young patients [age < 23 years; mean follow-up of 4.9 (range 2.5-8.1) years] enrolled in VALIGA, a study designed to validate the Oxford Classification of IgAN, were assessed. Renal biopsies were scored for the presence of mesangial hypercellularity (M1), endocapillary hypercellularity (E1), segmental glomerulosclerosis (S1), tubular atrophy/interstitial fibrosis (T1-2) (MEST score) and crescents (C1). Progression was assessed as end stage renal disease and/or a 50 % loss of estimated glomerular filtration rate (eGFR) (combined endpoint) as well as the rate of renal function decline (slope of eGFR). Cox regression and tree classification binary models were used and compared. In this cohort of 261 subjects aged < 23 years, Cox analysis validated the MEST M, S and T scores for predicting survival to the combined endpoint but failed to prove that these scores had predictive value in the sub-group of 174 children aged < 18 years. The regression tree classification indicated that patients with M1 were at risk of developing higher time-averaged proteinuria (p < 0.0001) and the combined endpoint (p < 0.001). An initial proteinuria of ae0.4 g/day/1.73 m(2) and an eGFR of < 90 ml/min/1.73 m(2) were determined to be risk factors in subjects with M0. Children aged < 16 years with M0 and well-preserved eGFR (> 90 ml/min/1.73 m(2)) at presentation had a significantly high probability of proteinuria remission during follow-up and a higher remission rate following treatment with corticosteroid and/or immunosuppressive therapy. This new statistical approach has identified clinical and histological risk factors associated with outcome in children and young adults with IgAN.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- IgA nephropathy
- Progression
- Pathology classification
- Proteinuria
- Risk factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Coppo, Rosanna
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Lofaro, Danilo
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Camilla, Roberta ...
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Bellur, Shubha
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Cattran, Daniel
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Cook, H. Terence
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show more...
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Roberts, Ian S. ...
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Peruzzi, Licia
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Amore, Alessandr ...
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Emma, Francesco
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Fuiano, Laura
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Berg, Ulla
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Topaloglu, Rezan
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Bilginer, Yelda.
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Gesualdo, Loreto
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Polci, Rosaria
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Mizerska-Wasiak, ...
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Caliskan, Yasar
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Lundberg, Sigrid
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Cancarini, Giova ...
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Geddes, Colin
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Wetzels, Jack
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Wiecek, Andrzej
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Durlik, Magdalen ...
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Cusinato, Stefan ...
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Rollino, Cristia ...
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Maggio, Milena
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Praga, Manuel
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Smerud, Hilde Kl ...
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Tesar, Vladimir
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Maixnerova, Dita
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Barratt, Jonatha ...
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Papalia, Teresa
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Bonofiglio, Renz ...
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Mazzucco, Gianna
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Giannakakis, Cos ...
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Söderberg, Magnu ...
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Orhan, Diclehan
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Di Palma, Anna M ...
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Maldyk, Jadwiga
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Ozluk, Yasemin
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Sudelin, Birgitt ...
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Tardanico, Regin ...
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Kipgen, David
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Steenbergen, Eri ...
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Karkoszka, Henry ...
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Perkowska-Ptasin ...
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Ferrario, Franco
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Gutierrez, Eduar ...
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Honsova, Eva
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Pediatric nephro ...
- By the university
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Uppsala University
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Karolinska Institutet