Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:uu-313971" > Specific histone mo...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Carranza, Pedro G.Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;CITSE, Santiago Del Estero, Argentina. (author)

Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia

Article/chapterEnglish2016

Publisher, publication year, extent ...

Elsevier BV,2016
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-313971
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-313971URI
https://doi.org/10.1016/j.biocel.2016.10.010DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Pedro G. Carranza and Pablo R. Gargantini acontributed equally to this work.
During evolution, parasitic microorganisms have faced the challenges of adapting to different environments to colonize a variety of hosts. Giardia lamblia, a common cause of intestinal disease, has developed fascinating strategies to adapt both outside and inside its host's intestine, such as trophozoite differentiation into cyst and the switching of its major surface antigens. How gene expression is regulated during these adaptive processes remains undefined. Giardia lacks some typical eukaryotic features, like canonical transcription factors, linker histone H1, and complex promoter regions; suggesting that post transcriptional and translational control of gene expression is essential for parasite survival. However, epigenetic factors may also play critical roles at the transcriptional level. Here, we describe the most common post -translational histone modifications; characterize enzymes involved in these reactions, and analyze their association with the Giardia's differentiation processes. We present evidence that NAD(+)-dependent and NAD(+)-independent histone deacetylases regulate encystation; however, a unique NAD(+)-independent histone deacetylase modulate antigenic switching. The rates of acetylation of H4K8 and H4K16 are critical for encystation, whereas a decrease in acetylation of H4K8 and methylation of H3K9 occur preferentially during antigenic variation. These results show the complexity of the mechanisms regulating gene expression in this minimalistic protozoan parasite.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
Histone marks
Cellular differentiation
Gene regulation
Histone methylases
Histone deacetylases
HDAC
Sirtuin

Added entries (persons, corporate bodies, meetings, titles ...)

Gargantini, Pablo R.Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Consejo Nacl Invest Cient & Tecn, Ctr Invest & Desarrollo Inmunol & Enfermedades In, Cordoba, Argentina. (author)
Prucca, Cesar G.Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Ctr Invest Quim Biol Cordoba CIQUIBIC, Cordoba, Argentina. (author)
Torri, AlessandroUniv Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina. (author)
Saura, AliciaUniv Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Consejo Nacl Invest Cient & Tecn, Ctr Invest & Desarrollo Inmunol & Enfermedades In, Cordoba, Argentina. (author)
Svärd, StaffanUppsala universitet,Mikrobiologi(Swepub:uu)stsva021 (author)
Lujan, Hugo D.Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Consejo Nacl Invest Cient & Tecn, Ctr Invest & Desarrollo Inmunol & Enfermedades In, Cordoba, Argentina. (author)
Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;CITSE, Santiago Del Estero, Argentina.Univ Catolica Cordoba, Fac Med, Lab Bioquim & Biol Mol, Cordoba, Argentina.;Consejo Nacl Invest Cient & Tecn, Ctr Invest & Desarrollo Inmunol & Enfermedades In, Cordoba, Argentina. (creator_code:org_t)

Related titles

In:International Journal of Biochemistry and Cell Biology: Elsevier BV81, s. 32-431357-27251878-5875

Internet link

Find in a library

International Journal of Biochemistry and Cell Biology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Carranza, Pedro ...; Gargantini, Pabl ...; Prucca, Cesar G.; Torri, Alessandr ...; Saura, Alicia; Svärd, Staffan; show more...; Lujan, Hugo D.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Medical Biotechn ...

Articles in the publication: International Jo ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se