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Uric acid and endot...
Uric acid and endothelial function in elderly community-dwelling subjects
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Ticinesi, Andrea (author)
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Lauretani, Fulvio (author)
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Ceda, Gian Paolo (author)
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Ruggiero, Carmelinda (author)
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Ferrucci, Luigi (author)
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Aloe, Rosalia (author)
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- Larsson, Anders (author)
- Uppsala universitet,Biokemisk struktur och funktion
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- Cederholm, Tommy (author)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Meschi, Tiziana (author)
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Maggio, Marcello (author)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Experimental Gerontology. - : Elsevier BV. - 0531-5565 .- 1873-6815. ; 89, s. 57-63
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The role of serum uric acid (SUA), an inflammatory agent and potential mediator of cardiovascular diseases, in endothelial function (EF) has been tested only in middle-aged subjects affected by specific diseases. Our aim was to assess the relationship between SUA and measures of EF in a cohort of elderly community-dwellers. This study involved 424 males and 426 females aged 70years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), having complete data on SUA and EF assessed by flow-mediated vasodilation (FMD) and by intra-arterial infusion of acetylcholine (endothelium-dependent vasodilation, EDV) and sodium nitroprusside (endothelium-independent vasodilation, EIDV). Univariate and multivariate regression models obtained by backward selection from initial fully-adjusted models were built to assess the relationship between SUA and measures of EF in both genders. Cardiovascular risk factors, serum hormonal and metabolic mediators, and body composition were considered as potential confounders. In the univariate model, SUA was inversely associated in both genders with log(EDV) (β±SE males -0.39±0.17, p=0.03; females -0.57±0.19, p=0.003) and log(EIDV) (males -0.23±0.12, p=0.05; females -0.49±0.15, p=0.002), but not with log(FMD). After adjustment for BMI, only the association between SUA and log(EIDV) in females persisted, though attenuated (-0.32±0.16, p=0.049), and was no longer significant in the fully-adjusted multivariate model including waist/hip ratio. In conclusion, in older subjects, especially women, SUA is associated with EF not independently of a list of confounders including BMI and trunk fat mass, suggesting a role as surrogate metabolic marker rather than an active player in EF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ticinesi, Andrea
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Lauretani, Fulvi ...
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Ceda, Gian Paolo
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Ruggiero, Carmel ...
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Ferrucci, Luigi
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Aloe, Rosalia
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show more...
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Larsson, Anders
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Cederholm, Tommy
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Lind, Lars
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Meschi, Tiziana
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Maggio, Marcello
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Experimental Ger ...
- By the university
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Uppsala University
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Karolinska Institutet