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Uric acid and endot...
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Ticinesi, Andrea
(author)
Uric acid and endothelial function in elderly community-dwelling subjects
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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Elsevier BV,2017
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-314144
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-314144URI
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https://doi.org/10.1016/j.exger.2016.12.012DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135406792URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The role of serum uric acid (SUA), an inflammatory agent and potential mediator of cardiovascular diseases, in endothelial function (EF) has been tested only in middle-aged subjects affected by specific diseases. Our aim was to assess the relationship between SUA and measures of EF in a cohort of elderly community-dwellers. This study involved 424 males and 426 females aged 70years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), having complete data on SUA and EF assessed by flow-mediated vasodilation (FMD) and by intra-arterial infusion of acetylcholine (endothelium-dependent vasodilation, EDV) and sodium nitroprusside (endothelium-independent vasodilation, EIDV). Univariate and multivariate regression models obtained by backward selection from initial fully-adjusted models were built to assess the relationship between SUA and measures of EF in both genders. Cardiovascular risk factors, serum hormonal and metabolic mediators, and body composition were considered as potential confounders. In the univariate model, SUA was inversely associated in both genders with log(EDV) (β±SE males -0.39±0.17, p=0.03; females -0.57±0.19, p=0.003) and log(EIDV) (males -0.23±0.12, p=0.05; females -0.49±0.15, p=0.002), but not with log(FMD). After adjustment for BMI, only the association between SUA and log(EIDV) in females persisted, though attenuated (-0.32±0.16, p=0.049), and was no longer significant in the fully-adjusted multivariate model including waist/hip ratio. In conclusion, in older subjects, especially women, SUA is associated with EF not independently of a list of confounders including BMI and trunk fat mass, suggesting a role as surrogate metabolic marker rather than an active player in EF.
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Lauretani, Fulvio
(author)
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Ceda, Gian Paolo
(author)
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Ruggiero, Carmelinda
(author)
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Ferrucci, Luigi
(author)
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Aloe, Rosalia
(author)
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Larsson, AndersUppsala universitet,Biokemisk struktur och funktion(Swepub:uu)andlarss
(author)
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Cederholm, TommyKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)tomce419
(author)
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(author)
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Meschi, Tiziana
(author)
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Maggio, Marcello
(author)
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Uppsala universitetBiokemisk struktur och funktion
(creator_code:org_t)
Related titles
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In:Experimental Gerontology: Elsevier BV89, s. 57-630531-55651873-6815
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Ticinesi, Andrea
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Lauretani, Fulvi ...
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Ceda, Gian Paolo
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Ruggiero, Carmel ...
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Ferrucci, Luigi
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Aloe, Rosalia
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Larsson, Anders
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Cederholm, Tommy
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Lind, Lars
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Meschi, Tiziana
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Maggio, Marcello
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Uppsala University
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Karolinska Institutet