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Correlations between the enantio- and regio-selective metabolisms of warfarin

Takahashi, Harumi (author)
Meiji Pharmaceut Univ, Dept Biopharmaceut, Tokyo, Japan.
Ohara, Minami (author)
Meiji Pharmaceut Univ, Dept Biopharmaceut, Tokyo, Japan.
Shibata, Soichi (author)
Kitasato Univ, Kitasato Inst Hosp, Dept Pharm, Tokyo, Japan.
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Lee, Ming Ta Michael (author)
Geisinger Hlth Syst, Danville, PA USA.;Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.
Cavallari, Larisa H. (author)
Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA.
Nutescu, Edith A. (author)
Univ Illinois, Dept Pharm Practice, Chicago, IL USA.
Scordo, Maria Gabriella (author)
Uppsala universitet,Klinisk farmakogenomik och osteoporos
Pengo, Vittorio (author)
Univ Padua, Dept Cardiothorac & Vasc Sci, Padua, Italy.
Padrini, Roberto (author)
Univ Padua, Dept Med DIMED, Padua, Italy.
Atsuda, Koichiro (author)
Kitasato Univ Hosp, Dept Pharm, Sagamihara, Kanagawa, Japan.
Matsubara, Hajime (author)
Kitasato Univ, Kitasato Inst Hosp, Dept Pharm, Tokyo, Japan.
Chen, Yuan Tsong (author)
Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.
Echizen, Hirotoshi (author)
Meiji Pharmaceut Univ, Dept Pharmacotherapy, Tokyo, Japan.
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Meiji Pharmaceut Univ, Dept Biopharmaceut, Tokyo, Japan Kitasato Univ, Kitasato Inst Hosp, Dept Pharm, Tokyo, Japan. (creator_code:org_t)
Future Medicine Ltd, 2017
2017
English.
In: Pharmacogenomics (London). - : Future Medicine Ltd. - 1462-2416 .- 1744-8042. ; 18:2, s. 133-142
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https://urn.kb.se/re...
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https://doi.org/10.2...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Aim: To clarify whether the activities of multiple CYPs associated with warfarin metabolism would be correlated with each other. Methods: Oral clearances (CLpo) of warfarin enantiomers were estimated in 378 Chinese, Caucasians and African-Americans. The partial metabolic clearances (CLm) for 7-hydroxywarfarin enantiomers were also measured. In addition, CLpo and CLm were determined in a patient on warfarin and rifampicin. Results: Correlations between CLpo for warfarin enantiomers existed across the three populations. In addition, there was a significant correlation between the CLm for 7-hydroxylation of warfarin enantiomers. Under induced conditions by rifampicin, there were significant correlations between the enantio-and regio-selective metabolisms of warfarin. Conclusion: Metabolic activities of CYP2C9, CYP1A2 and CYP3A4 may be regulated by common transcriptional mechanism(s).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Keyword

CYP1A2
CYP2C9
CYP3A4
metabolism
transcriptional factors
warfarin enantiomers

Publication and Content Type

ref (subject category)
art (subject category)

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