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Low to moderate lif...
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Hagström, HannesKarolinska Institutet,Karolinska Institute, Sweden
(author)
Low to moderate lifetime alcohol consumption is associated with less advanced stages of fibrosis in non-alcoholic fatty liver disease
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2016-10-06
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Informa UK Limited,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-316134
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316134URI
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https://doi.org/10.1080/00365521.2016.1239759DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135046218URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-134618URI
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https://gup.ub.gu.se/publication/247090URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Stockholm County Council (ALF) [20140329, 20150403]; Royal Swedish Academy of Sciences Foundations [ME2015-0011]; Swedish Society of Medicine (Gastroenterology Fund); Ruth and Richard Julins Fund; ALF [2015403]
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Background and aim: Moderate alcohol consumption has been associated with a lower risk of disease severity in non-alcoholic fatty liver disease (NAFLD). It is unclear if this reflects current or lifetime drinking, or can be attributed to confounders such as diet and exercise. We evaluated the impact of lifetime alcohol consumption on fibrosis severity in NAFLD. Methods: We prospectively enrolled 120 subjects with biopsy-proven NAFLD and through detailed questionnaires examined lifetime alcohol consumption, diet and physical activity. Main outcome measures were odds ratios (OR) for fibrosis stage, calculated through ordinal regression after adjustment for body mass index, diabetes mellitus type 2, smoking and age at biopsy. A biomarker for recent alcohol consumption, phosphatidyl ethanol (PEth) was sampled. Results: An increase in median weekly alcohol consumption to a maximum of 13 drinks per week was associated with lower fibrosis stage (adjusted OR for each incremental unit, 0.86; 95% CI, 0.76-0.97; p = .017). The lowest risk for fibrosis was found with the lowest odds seen in the top quartile of alcohol consumption (aOR 0.23; 95% CI 0.08-0.66; p = .006). Adding soft drink and coffee consumptions, and physical activity to the model did not change the estimates. Subjects with PEth >= 0.3 mu mol/L had higher ORs for a higher fibrosis stage (aOR 2.77; 95% CI 1.01-7.59; p = .047). Conclusion: Lifetime alcohol consumption with up to 13 units per week is associated with lower fibrosis stage in NAFLD. Elevated PEth is associated with higher stages of fibrosis.
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Nasr, Patrik,1987-Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken(Swepub:liu)patna19
(author)
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Ekstedt, MattiasLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken(Swepub:liu)matek92
(author)
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Kechagias, StergiosLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken(Swepub:liu)steke00
(author)
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Önnerhag, KristinaSkane Univ Hosp, Dept Gastroenterol & Hepatol, Malmo, Sweden.,Skåne University Hospital, Sweden
(author)
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Nilsson, EmmaSkane Univ Hosp, Dept Gastroenterol & Hepatol, Malmo, Sweden.,Skåne University Hospital, Sweden
(author)
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Rorsman, FredrikUppsala universitet,Gastroenterologi/hepatologi,University of Uppsala Hospital, Sweden(Swepub:uu)fredrikr
(author)
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Sheikhi, RezaUppsala universitet,Gastroenterologi/hepatologi,University of Uppsala Hospital, Sweden(Swepub:uu)rezsh525
(author)
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Marschall, Hanns-UlrichGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xmarsh
(author)
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Hultcrantz, RolfKarolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
(author)
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Stål, PerKarolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden
(author)
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Karolinska InstitutetKarolinska Institute, Sweden
(creator_code:org_t)
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In:Scandinavian Journal of Gastroenterology: Informa UK Limited52:2, s. 159-1650036-55211502-7708
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