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- Bergman, LinaUppsala universitet,Obstetrik & gynekologi,Clin Res Ctr, Dalarna, Sweden.,Obstetrisk forskning (author)
Cerebral Biomarkers in Women With Preeclampsia Are Still Elevated 1 Year Postpartum
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2016-09-21
- Oxford University Press (OUP),2016
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- LIBRIS-ID:oai:DiVA.org:uu-316434
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316434URI
- https://doi.org/10.1093/ajh/hpw097DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:135051053URI
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- Language:English
- Summary in:English
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- BACKGROUND There is evidence of cerebral involvement among women with preeclampsia. Levels of the cerebral biomarkers neuron-specific enolase (NSE) and S100B are elevated during pregnancy in women developing preeclampsia. It is although not known if these biomarkers return to normal range postpartum. The aim with this study was to compare levels of S100B and NSE during pregnancy and 1 year postpartum in women who have had preeclampsia to women with normal pregnancies. METHODS This study was a longitudinal study of cases (n = 53) with preeclampsia and controls (n = 58) consisted of normal pregnant women in matched gestational weeks. Plasma samples were collected at inclusion during pregnancy and 1 year postpartum. Plasma samples were analyzed for levels of S100B and NSE by enzyme-linked immunosorbent assays kits. RESULTS Levels of NSE and S100B in women with preeclampsia were higher during pregnancy than in women with normal pregnancies. One year postpartum, women who have had preeclampsia still had a higher median level of both NSE (5.07 vs. 4.28 mu g/l, P < 0.05) and S100B (0.07 vs. 0.06 mu g/l, P < 0.05) compared to women with previous normal pregnancies. High levels of NSE and S100B postpartum remained associated with previous preeclampsia after adjustment for confounding factors. Levels of NSE correlated to S100B during pregnancy and postpartum. CONCLUSIONS Levels of NSE and S100B are still elevated 1 year postpartum in women who have had preeclampsia in contrast to women with previous normal pregnancies. We hypothesize that there might be a persistent cerebral involvement among women with preeclampsia even 1 year postpartum.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
- blood pressure
- hypertension
- Neurological dysfunction
- NSE
- preeclampsia
- S100B
Added entries (persons, corporate bodies, meetings, titles ...)
- Åkerud, Helena,1972-Uppsala universitet,Obstetrik & gynekologi,Reproduktiv hälsa(Swepub:uu)helelars (author)
- Wikström, Anna KarinKarolinska Institutet,Uppsala universitet,Obstetrik & gynekologi,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Stockholm, Sweden.,Obstetrisk forskning(Swepub:uu)annwi179 (author)
- Larsson, MaritaUppsala universitet,Obstetrik & gynekologi (author)
- Naessén, TordUppsala universitet,Obstetrik & gynekologi,Gynekologisk endokrinologi(Swepub:uu)tordnaes (author)
- Akhter, TansimUppsala universitet,Obstetrik & gynekologi,Gynekologisk endokrinologi(Swepub:uu)tanak729 (author)
- , ring (author)
- Uppsala universitetObstetrik & gynekologi (creator_code:org_t)
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- In:American Journal of Hypertension: Oxford University Press (OUP)29:12, s. 1374-13790895-70611941-7225
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