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The Use of Immunohi...
The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases
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- Thunnissen, Erik (author)
- Vrije Univ Amsterdam Med Ctr, Dept Pathol, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
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- Borczuk, Alain C. (author)
- Weill Cornell Med, Dept Pathol, New York, NY USA.
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- Flieder, Douglas B. (author)
- Fox Chase Canc Ctr, Dept Pathol, Philadelphia, PA 19111 USA.
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- Witte, Birgit (author)
- Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands.
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- Beasley, Mary Beth (author)
- Mt Sinai Med Ctr, Dept Pathol, New York, NY 10029 USA.
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- Chung, Jin-Haeng (author)
- Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Pathol, Seoul 151, South Korea.
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- Dacic, Sanja (author)
- Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA.
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- Lantuejoul, Sylvie (author)
- Ctr Leon Berard UNICANCER, Dept Biopathol, Lyon, France.
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- Russell, Prudence A. (author)
- St Vincent Pathol, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.
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- den Bakker, Michael (author)
- Maasstad Ziekenhuis, Dept Pathol, Rotterdam, Netherlands.
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- Botling, Johan (author)
- Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
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- Brambilla, Elisabeth (author)
- CHU Albert Michallon, Inst Biol, Dept Anat & Cytol Pathol, Grenoble, France.
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- de Cuba, Erienne (author)
- Vrije Univ Amsterdam Med Ctr, Dept Pathol, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
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- Geisinger, Kim R. (author)
- Univ Mississippi, Med Ctr, Dept Pathol, Jackson, MS 39216 USA.
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- Hiroshima, Kenzo (author)
- Tokyo Womens Med Univ, Yachiyo Med Ctr, Dept Pathol, Yachiyo, Japan.
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- Marchevsky, Alberto M. (author)
- Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA 90048 USA.
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- Minami, Yuko (author)
- Univ Tsukuba, Inst Basic Med Sci, Dept Pathol, Tsukuba, Ibaraki, Japan.
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- Moreira, Andre (author)
- NYU, Ctr Biospecimen Res & Dev, Pulm Pathol, New York, NY USA.
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- Nicholson, Andrew G. (author)
- Royal Brompton & Harefield Hosp Natl Hlth Serv Fd, Dept Histopathol, London, England.;Imperial Coll, Natl Heart & Lung Inst, London, England.
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- Yoshida, Akihiko (author)
- Natl Canc Ctr, Dept Pathol & Clin Labs, Tokyo, Japan.
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- Tsao, Ming-Sound (author)
- Princess Margaret Hosp, Univ Hlth Network, Dept Pathol, Toronto, ON, Canada.;Univ Toronto, Toronto, ON, Canada.
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- Warth, Arne (author)
- Heidelberg Univ, Inst Pathol, Heidelberg, Germany.
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- Duhig, Edwina (author)
- John Flynn Hosp, Sullivan Nicolaides Pathol, Tugun, Qld, Australia.
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- Chen, Gang (author)
- Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai, Peoples R China.
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- Matsuno, Yoshihiro (author)
- Hokkaido Univ Hosp, Dept Surg Pathol, Sapporo, Hokkaido, Japan.
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- Travis, William D. (author)
- Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA.
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- Butnor, Kelly (author)
- Univ Vermont, Dept Pathol, Burlington, VT 05405 USA.
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- Cooper, Wendy (author)
- Royal Prince Alfred Hosp, Tissue Pathol & Diagnost Oncol, Sydney, NSW, Australia.
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- Mino-Kenudson, Mari (author)
- Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA USA.
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- Motoi, Noriko (author)
- Natl Canc Ctr, Dept Pathol & Clin Labs, Tokyo, Japan.
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- Poleri, Claudia (author)
- Lab Patol Torac, Buenos Aires, DF, Argentina.
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- Pelosi, Giuseppe (author)
- Univ Milan, Dept Oncol & Hematol Oncol, Milan, Italy.
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- Kerr, Keith (author)
- Aberdeen Royal Infirm, Dept Pathol, Aberdeen, Scotland.
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- Aisner, Seena C. (author)
- Rutgers State Univ, Rutgers New Jersey Med Sch, Dept Pathol & Lab Med, Newark, NJ USA.
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- Ishikawa, Yuichi (author)
- Japan Fdn Canc Res, Inst Canc, Div Pathol, Tokyo, Japan.
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- Buettner, Reinhard H. (author)
- Cologne Inst Pathol, Cologne, Germany.
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- Keino, Naoto (author)
- Univ Tsukuba, Tsukuba Clin Res & Dev Org, Tsukuba, Ibaraki, Japan.
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- Yatabe, Yasushi (author)
- Aichi Canc Ctr, Dept Pathol & Mol Diagnost, Nagoya, Aichi, Japan.
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- Noguchi, Masayuki (author)
- Univ Tsukuba, Inst Basic Med Sci, Dept Pathol, Tsukuba, Ibaraki, Japan.
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Vrije Univ Amsterdam Med Ctr, Dept Pathol, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands Weill Cornell Med, Dept Pathol, New York, NY USA. (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Journal of Thoracic Oncology. - : Elsevier BV. - 1556-0864 .- 1556-1380. ; 12:2, s. 334-346
- Related links:
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http://www.jto.org/a...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction: The current WHO classification of lung cancer states that a diagnosis of SCLC can be reliably made on routine histological and cytological grounds but immunohistochemistry (IHC) may be required, particularly (1) in cases in which histologic features are equivocal and (2) in cases in which the pathologist wants to increase confidence in diagnosis. However, reproducibility studies based on hematoxylin and eosin-stained slides alone for SCLC versus large cell neuroendocrine carcinoma (LCNEC) have shown pairwise K scores ranging from 0.35 to 0.81. This study examines whether judicious use of IHC improves diagnostic reproducibility for SCLC.Methods: Nineteen lung pathologists studied interactive digital images of 79 tumors, predominantly neuroendocrine lung tumors. Images of resection and biopsy specimens were used to make diagnoses solely on the basis of morphologic features (level 1), morphologic features along with requested IHC staining results (level 2), and all available IHC staining results (level 3).Results: For the 19 pathologists reading all 79 cases, the rate of agreement for level 1 was 64.7%, and it increased to 73.2% and 77.5% in levels 2 and 3, respectively. With IHC, K scores for four tumor categories (SCLC, LCNEC, carcinoid tumors, and other) increased in resection samples from 0.43 to 0.60 and in biopsy specimens from 0.43 to 0.64.Conclusions: Diagnosis using hematoxylin and eosin staining alone showeds moderate agreement among pathologists in tumors with neuroendocrine morphology, but agreement improved to good in most cases with the judicious use of IHC, especially in the diagnosis of SCLC. An approach for IHC in the differential diagnosis of SCLC is provided. (C) 2017 International Association for the Study of Lung Cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- SCLC
- Histopathology
- Reproducibility
- Immunohistochemistry
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Thunnissen, Erik
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Borczuk, Alain C ...
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Flieder, Douglas ...
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Witte, Birgit
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Beasley, Mary Be ...
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Chung, Jin-Haeng
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show more...
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Dacic, Sanja
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Lantuejoul, Sylv ...
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Russell, Prudenc ...
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den Bakker, Mich ...
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Botling, Johan
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Brambilla, Elisa ...
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de Cuba, Erienne
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Geisinger, Kim R ...
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Hiroshima, Kenzo
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Marchevsky, Albe ...
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Minami, Yuko
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Moreira, Andre
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Nicholson, Andre ...
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Yoshida, Akihiko
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Tsao, Ming-Sound
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Warth, Arne
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Duhig, Edwina
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Chen, Gang
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Matsuno, Yoshihi ...
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Travis, William ...
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Butnor, Kelly
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Cooper, Wendy
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Mino-Kenudson, M ...
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Motoi, Noriko
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Poleri, Claudia
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Pelosi, Giuseppe
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Kerr, Keith
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Aisner, Seena C.
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Ishikawa, Yuichi
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Buettner, Reinha ...
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Keino, Naoto
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Yatabe, Yasushi
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Noguchi, Masayuk ...
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- MEDICAL AND HEALTH SCIENCES
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Uppsala University