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Ameloblastoma RNA p...
Ameloblastoma RNA profiling uncovers a distinct non-coding RNA signature
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- Davanian, Haleh (author)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.
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- Balasiddaiah, Anangi (author)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;Karolinska Inst, Dept Lab Med, Huddinge, Sweden.
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- Heymann, Robert (author)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;Karolinska Univ Hosp, Clin Oral & Maxillofacial Surg, Huddinge, Sweden.
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- Sundström, Magnus (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Univ Uppsala Hosp, Dept Pathol, Mol Pathol Unit, Rudbecklab, Uppsala, Sweden.
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- Redenström, Poppy (author)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.
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- Silfverberg, Mikael (author)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.
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- Brodin, David (author)
- Karolinska Inst, Dept Biosci & Nutr, Bioinformat & Express Anal SciLifeLab, Huddinge, Sweden.
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- Sällberg, Matti (author)
- Karolinska Inst, Dept Lab Med, Huddinge, Sweden.
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- Lindskog, Sven (author)
- Karolinska Inst, Dept Pathol & Oncol, Huddinge, Sweden.;Karolinska Univ Hosp, Clin Pathol & Cytol, Solna, Sweden.
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- Weiner, Carina Kruger (author)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;Karolinska Univ Hosp, Clin Oral & Maxillofacial Surg, Huddinge, Sweden.
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- Chen, Margaret (author)
- Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;Karolinska Inst, Dept Lab Med, Huddinge, Sweden.
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Karolinska Inst, Dept Dent Med, Huddinge, Sweden Karolinska Inst, Dept Dent Med, Huddinge, Sweden.;Karolinska Inst, Dept Lab Med, Huddinge, Sweden. (creator_code:org_t)
- 2016-12-10
- 2017
- English.
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In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:3, s. 4530-4542
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Ameloblastoma of the jaws remains the top difficult to treat odontogenic tumour and has a high recurrence rate. New evidence suggests that non-coding RNAs (ncRNAs) play a critical role in tumourgenesis and prognosis of cancer. However, ameloblastoma ncRNA expression data is lacking. Here we present the first report of ameloblastoma ncRNA signatures. A total of 95 ameloblastoma cases and a global array transcriptome technology covering > 285.000 full-length transcripts were used in this two-step analysis. The analysis first identified in a test cohort 31 upregulated ameloblastoma-associated ncRNAs accompanied by signalling pathways of cancer, spliceosome, mRNA surveillance and Wnt. Further validation in an independent cohort points out the long non-coding (lncRNAs) and small nucleolar RNA (snoRNAs): LINC340, SNORD116-25, SNORA11, SNORA21, SNORA47 and SNORA65 as a distinct ncRNA signature of ameloblastoma. Importantly, the presence of these ncRNAs was independent of BRAFV600E and SMO-L412F mutations, histology type or tumour location, but was positively correlated with the tumour size. Taken together, this study shows a systematic investigation of ncRNA expression of ameloblastoma, and illuminates new diagnostic and therapeutic targets for this invasive odontogenic tumour.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- ameloblastoma
- biomarkers
- transcriptome
- ncRNA
- gene expression analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Davanian, Haleh
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Balasiddaiah, An ...
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Heymann, Robert
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Sundström, Magnu ...
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Redenström, Popp ...
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Silfverberg, Mik ...
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Brodin, David
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Sällberg, Matti
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Lindskog, Sven
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Weiner, Carina K ...
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Chen, Margaret
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- MEDICAL AND HEALTH SCIENCES
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Oncotarget
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Uppsala University