Search: onr:"swepub:oai:DiVA.org:uu-317725" > Parametric Methods ...
Fältnamn | Indikatorer | Metadata |
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000 | 03319naa a2200481 4500 | |
001 | oai:DiVA.org:uu-317725 | |
003 | SwePub | |
008 | 170317s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3177252 URI |
024 | 7 | a https://doi.org/10.2967/jnumed.116.1787072 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mansor, Syahir4 aut |
245 | 1 0 | a Parametric Methods for Dynamic (11)C-Phenytoin PET Studies. |
264 | c 2016-09-22 | |
264 | 1 | b Society of Nuclear Medicine,c 2017 |
338 | a print2 rdacarrier | |
520 | a In this study, the performance of various methods for generating quantitative parametric images of dynamic (11)C-phenytoin PET studies was evaluated. Methods: Double-baseline 60-min dynamic (11)C-phenytoin PET studies, including online arterial sampling, were acquired for 6 healthy subjects. Parametric images were generated using Logan plot analysis, a basis function method, and spectral analysis. Parametric distribution volume (VT) and influx rate (K1) were compared with those obtained from nonlinear regression analysis of time-activity curves. In addition, global and regional test-retest (TRT) variability was determined for parametric K1 and VT values. Results: Biases in VT observed with all parametric methods were less than 5%. For K1, spectral analysis showed a negative bias of 16%. The mean TRT variabilities of VT and K1 were less than 10% for all methods. Shortening the scan duration to 45 min provided similar VT and K1 with comparable TRT performance compared with 60-min data. Conclusion: Among the various parametric methods tested, the basis function method provided parametric VT and K1 values with the least bias compared with nonlinear regression data and showed TRT variabilities lower than 5%, also for smaller volume-of-interest sizes (i.e., higher noise levels) and shorter scan duration. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
653 | a 11C-phenytoin | |
653 | a PET quantification | |
653 | a parametric kinetic modeling | |
653 | a test-retest variability | |
700 | 1 | a Yaqub, Maqsood4 aut |
700 | 1 | a Boellaard, Ronald4 aut |
700 | 1 | a Froklage, Femke E4 aut |
700 | 1 | a de Vries, Anke4 aut |
700 | 1 | a Bakker, Esther D M4 aut |
700 | 1 | a Voskuyl, Rob A4 aut |
700 | 1 | a Eriksson, Jonasu Uppsala universitet,Avdelningen för Molekylär Avbildning4 aut0 (Swepub:uu)joeri542 |
700 | 1 | a Schwarte, Lothar A4 aut |
700 | 1 | a Verbeek, Joost4 aut |
700 | 1 | a Windhorst, Albert D4 aut |
700 | 1 | a Lammertsma, Adriaan A4 aut |
710 | 2 | a Uppsala universitetb Avdelningen för Molekylär Avbildning4 org |
773 | 0 | t Journal of Nuclear Medicined : Society of Nuclear Medicineg 58:3, s. 479-483q 58:3<479-483x 0161-5505x 1535-5667x 2159-662X |
856 | 4 | u http://jnm.snmjournals.org/content/58/3/479.full.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317725 |
856 | 4 8 | u https://doi.org/10.2967/jnumed.116.178707 |
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