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Parametric Binding ...
Parametric Binding Images of the TSPO Ligand 18F-DPA-714.
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Golla, Sandeep S V (author)
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Boellaard, Ronald (author)
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Oikonen, Vesa (author)
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Hoffmann, Anja (author)
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van Berckel, Bart N M (author)
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Windhorst, Albert D (author)
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Virta, Jere (author)
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Te Beek, Erik T (author)
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Groeneveld, Geert Jan (author)
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Haaparanta-Solin, Merja (author)
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Luoto, Pauliina (author)
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Savisto, Nina (author)
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Solin, Olof (author)
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Valencia, Ray (author)
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Thiele, Andrea (author)
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- Eriksson, Jonas (author)
- Uppsala universitet,Avdelningen för Molekylär Avbildning
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Schuit, Robert C (author)
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Lammertsma, Adriaan A (author)
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Rinne, Juha O (author)
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(creator_code:org_t)
- 2016-06-03
- 2016
- English.
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In: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 57:10, s. 1543-1547
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http://jnm.snmjourna...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
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- (18)F-labeled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide (DPA-714) is a radioligand for the 18-kDa translocator protein. The purpose of the present study was to identify the best method for generating quantitative parametric images of (18)F-DPA-714 binding.METHODS: Ninety-minute dynamic (18)F-DPA-714 PET scans with full arterial sampling from 6 healthy subjects and 9 Alzheimer disease (AD) patients were used. Plasma-input-based Logan graphical analysis and spectral analysis were used to generate parametric volume of distribution (VT) images. Five versions of Ichise, reference Logan, and 2 basis function implementations (receptor parametric mapping and simplified reference tissue model 2 [SRTM2]) of SRTM, all using gray matter cerebellum as the reference region, were applied to generate nondisplaceable binding potential (BPND) images.RESULTS: Plasma-input Logan analysis (r(2) = 0.99; slope, 0.88) and spectral analysis (r(2) = 0.99, slope, 0.93) generated estimates of VT that correlated well with values obtained using nonlinear regression. BPND values generated using SRTM2 (r(2) = 0.83; slope, 0.95) and reference Logan analysis (r(2) = 0.88; slope, 1.01) correlated well with nonlinear regression-based estimates.CONCLUSION: Both Logan analysis and spectral analysis can be used to obtain quantitatively accurate VT images of (18)F-DPA-714. In addition, SRTM2 and reference Logan analysis can provide accurate BPND images. These parametric images could be used for voxel-based comparisons.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- 18F-DPA-714
- PET
- TSPO
- parametric images
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Golla, Sandeep S ...
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Boellaard, Ronal ...
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Oikonen, Vesa
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Hoffmann, Anja
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van Berckel, Bar ...
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Windhorst, Alber ...
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show more...
-
Virta, Jere
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Te Beek, Erik T
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Groeneveld, Geer ...
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Haaparanta-Solin ...
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Luoto, Pauliina
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Savisto, Nina
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Solin, Olof
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Valencia, Ray
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Thiele, Andrea
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Eriksson, Jonas
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Schuit, Robert C
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Lammertsma, Adri ...
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Rinne, Juha O
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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Journal of Nucle ...
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Uppsala University