Search: onr:"swepub:oai:DiVA.org:uu-317759" >
Antibody-secreting ...
Antibody-secreting plasma cells persist for decades in human intestine
-
Landsverk, Ole J. B. (author)
-
Snir, Omri (author)
-
Casado, Raquel Bartolome (author)
-
show more...
-
Richter, Lisa (author)
-
- Mold, Jeff E. (author)
- Karolinska Institutet
-
- Reu, Pedro (author)
- Karolinska Institutet
-
Horneland, Rune (author)
-
Paulsen, Vemund (author)
-
Yaqub, Sheraz (author)
-
Aandahl, Einar Martin (author)
-
Oyen, Ole M. (author)
-
Thorarensen, Hildur Sif (author)
-
- Salehpour, Mehran (author)
- Uppsala universitet,Tillämpad kärnfysik
-
- Possnert, Göran (author)
- Uppsala universitet,Tillämpad kärnfysik
-
- Frisen, Jonas (author)
- Karolinska Institutet
-
Sollid, Ludvig M. (author)
-
Baekkevold, Espen S. (author)
-
Jahnsen, Frode L. (author)
-
show less...
-
(creator_code:org_t)
- 2017-01-19
- 2017
- English.
-
In: Journal of Experimental Medicine. - NewYork, USA : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 214:2, s. 309-317
- Related links:
-
https://rupress.org/...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19(+) PC subset was dynamically exchanged, whereas of two CD19(-) PC subsets, CD45(+) PCs exhibited little and CD45(-) PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45(-) PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19(-) PC subsets support selection and maintenance of protective PCs for life in human intestine.
Subject headings
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Physics with specialization in Ion Physics
- Fysik med inriktning mot jonfysik
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Landsverk, Ole J ...
-
Snir, Omri
-
Casado, Raquel B ...
-
Richter, Lisa
-
Mold, Jeff E.
-
Reu, Pedro
-
show more...
-
Horneland, Rune
-
Paulsen, Vemund
-
Yaqub, Sheraz
-
Aandahl, Einar M ...
-
Oyen, Ole M.
-
Thorarensen, Hil ...
-
Salehpour, Mehra ...
-
Possnert, Göran
-
Frisen, Jonas
-
Sollid, Ludvig M ...
-
Baekkevold, Espe ...
-
Jahnsen, Frode L ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biophysics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Journal of Exper ...
- By the university
-
Uppsala University
-
Karolinska Institutet