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Circulating chromogranin B levels in patients with acute respiratory failure : data from the FINNALI Study
- Myhre, Peder Langeland (author)
-
- Stridsberg, Mats (author)
- Uppsala universitet,Biokemisk endokrinologi
- Linko, Rita (author)
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- Okkonen, Marjatta (author)
- Nygård, Ståle (author)
- Christensen, Geir (author)
- Pettilä, Ville (author)
- Omland, Torbjørn (author)
- Røsjø, Helge (author)
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- (creator_code:org_t)
- 2017
- 2017
- English.
- In: Biomarkers. - 1354-750X .- 1366-5804. ; 22:8, s. 775-781
- Journal article (peer-reviewed)
Abstract
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- PURPOSE: Circulating chromogranin B (CgB) levels are increased in situations characterized by systemic and myocardial stress, but whether CgB provides prognostic information in patients with acute respiratory failure (ARF) is unknown.METHODS: We included 584 patients with ARF, defined as ventilatory support >6 h, and with blood samples available on Intensive Care Unit (ICU) admission and day 3 (n = 479). CgB levels were measured by radioimmunoassay and follow-up was 90 days.RESULTS: One-hundred-sixty-nine patients (29%) died during follow-up. Admission CgB levels separated non-survivors from survivors: median 1234 (Q1-3 989-1742) vs. 917 (753-1224) pmol/L, respectively, p < 0.001. CgB levels on ICU admission (logarithmically transformed) were associated with time to death after adjustment for established risk indices available on ICU admission, including N-terminal pro-B-type natriuretic levels: HR 2.62 (95%C.I. 1.82-3.77), p < 0.001. Admission CgB levels also improved prognostication on top of SOFA and SAPS II scores as assessed by Cox regression analyses and the category-free net reclassification index. The area under the curve (AUC) for admission CgB levels to separate survivors and non-survivors was 0.72 (95%CI 0.67-0.76), while the AUC on day 3 was 0.60 (0.54-0.66).CONCLUSIONS: CgB levels measured on ICU admission provided additional prognostic information to established risk indices in ARF patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Chromogranin B
- acute respiratory failure
- biomarker
- prognosis
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