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Early-life adversit...
Early-life adversity and orbitofrontal and cerebellar volumes in adults with obsessive-compulsive disorder : voxel-based morphometry study.
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- Brooks, Samantha J (author)
- Uppsala universitet,Funktionell farmakologi
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Naidoo, Vanesh (author)
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Roos, Annerine (author)
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Fouché, Jean-Paul (author)
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Lochner, Christine (author)
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Stein, Dan J (author)
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(creator_code:org_t)
- 2018-01-02
- 2016
- English.
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In: British Journal of Psychiatry. - : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 208:1, s. 34-41
- Related links:
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https://www.cambridg...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Early-life adversity is a risk for obsessive-compulsive disorder (OCD), but the impact at the neural level is less clear.AIMS: To investigate the association between brain volumes and early-life adversity in individuals with a diagnosis of OCD only.METHOD: The Childhood Trauma Questionnaire (CTQ-28) was used to assess early-life adversity in 21 participants with OCD and 25 matched healthy controls. The relationship between global and regional brain volume and early-life adversity was measured using voxel-based morphometry (VBM). All data were corrected for multiple comparisons using family-wise error (FWE) at P<0.05.RESULTS: In the OCD group, correlations with total CTQ scores were positively associated with a larger right orbitofrontal cortex volume. Physical neglect was higher in the OCD group than in controls and was positively associated with larger right cerebellum volume in the OCD group only.CONCLUSIONS: Larger brain volumes may reflect underlying developmental neuropathology in adults with OCD who also have experience of childhood trauma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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