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Disrupting Glutamat...
Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation
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- Wang, Dong V. (author)
- NIDA, Behav Neurosci Branch, NIH, Baltimore, MD 21224 USA.
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- Viereckel, Thomas (author)
- Uppsala universitet,Institutionen för organismbiologi
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- Zell, Vivien (author)
- Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
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- Konradsson-Geuken, Åsa (author)
- Uppsala universitet,Jämförande fysiologi
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- Broker, Carl J. (author)
- NIDA, Behav Neurosci Branch, NIH, Baltimore, MD 21224 USA.
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- Talishinsky, Aleksandr (author)
- NIDA, Behav Neurosci Branch, NIH, Baltimore, MD 21224 USA.
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- Yoo, Ji Hoon (author)
- Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
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- Galinato, Melissa H. (author)
- Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
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- Arvidsson, Emma, 1986- (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Kesner, Andrew J. (author)
- Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
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- Hnasko, Thomas S. (author)
- Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
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- Wallén-Mackenzie, Åsa (author)
- Uppsala universitet,Jämförande fysiologi
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- Ikemoto, Satoshi (author)
- NIDA, Behav Neurosci Branch, NIH, Baltimore, MD 21224 USA.
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NIDA, Behav Neurosci Branch, NIH, Baltimore, MD 21224 USA Institutionen för organismbiologi (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 18:11, s. 2584-2591
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Dopamine neurons in the ventral tegmental area (VTA) were previously found to express vesicular glutamate transporter 2 (VGLUT2) and to co-transmit glutamate in the ventral striatum (VStr). This capacity may play an important role in reinforcement learning. Although it is known that activation of the VTA-VStr dopamine system readily reinforces behavior, little is known about the role of glutamate co-transmission in such reinforcement. By combining electrode recording and optogenetics, we found that stimulation of VTA dopamine neurons in vivo evoked fast excitatory responses in many VStr neurons of adult mice. Whereas conditional knockout of the gene encoding VGLUT2 in dopamine neurons largely eliminated fast excitatory responses, it had little effect on the acquisition of conditioned responses reinforced by dopamine neuron activation. Therefore, glutamate co-transmission appears dispensable for acquisition of conditioned responding reinforced by DA neuron activation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- glutamate co-transmission
- intracranial self-stimulation
- mesolimbic dopamine system
- nucleus accumbens
- reinforcement learning
- reward
- ventral striatum
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wang, Dong V.
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Viereckel, Thoma ...
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Zell, Vivien
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Konradsson-Geuke ...
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Broker, Carl J.
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Talishinsky, Ale ...
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show more...
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Yoo, Ji Hoon
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Galinato, Meliss ...
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Arvidsson, Emma, ...
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Kesner, Andrew J ...
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Hnasko, Thomas S ...
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Wallén-Mackenzie ...
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Ikemoto, Satoshi
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Reports
- By the university
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Uppsala University