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- Hellsten, Sofie V.Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Molekylär neurofarmakologi (author)
The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-02-24
- Public Library of Science (PLoS),2017
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-318954
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318954URI
- https://doi.org/10.1371/journal.pone.0172917DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- SLC38A9 is characterized as a lysosomal component of the amino acid sensing RagulatorRAG GTPase complex, controlling the mechanistic target of rapamycin complex 1 (mTORC1). Here, immunohistochemistry was used to map SLC38A9 in mouse brain and staining was detected throughout the brain, in cortex, hypothalamus, thalamus, hippocampus, brainstem and cerebellum. More specifically, immunostaining was found in areas known to be involved in amino acid sensing and signaling pathways e.g. piriform cortex and hypothalamus. SLC38A9 immunoreactivity co-localized with both GABAergic and glutamatergic neurons, but not with astrocytes. SLC38A9 play a key role in the mTORC1 pathway, and therefore we performed in vivo starvation and high-fat diet studies, to measure gene expression alterations in specific brain tissues and in larger brain regions. Following starvation, Slc38a9 was upregulated in brainstem and cortex, and in anterior parts of the brain (Bregma 3.2 to -2.1mm). After high-fat diet, Slc38a9 was specifically upregulated in hypothalamus, while overall downregulation was noticed throughout the brain (Bregma 3.2 to -8.6mm).
Added entries (persons, corporate bodies, meetings, titles ...)
- Eriksson, MikaelaUppsala universitet,Institutionen för farmaceutisk biovetenskap,Molekylär neurofarmakologi(Swepub:uu)miker725 (author)
- Lekholm, EmiliaUppsala universitet,Institutionen för farmaceutisk biovetenskap,Molekylär neurofarmakologi(Swepub:uu)emijo305 (author)
- Arapi, VasilikiUppsala universitet,Institutionen för farmaceutisk biovetenskap,Molekylär neurofarmakologi (author)
- Perland, EmelieUppsala universitet,Institutionen för farmaceutisk biovetenskap,Molekylär neurofarmakologi(Swepub:uu)emepe312 (author)
- Fredriksson, RorbertUppsala universitet,Institutionen för farmaceutisk biovetenskap,Molekylär neurofarmakologi(Swepub:uu)rfr20930 (author)
- Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)
Related titles
- In:PLOS ONE: Public Library of Science (PLoS)12:21932-6203
Internet link
- https://doi.org/10.1371/journal.pone.0172917Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1085802/FULLTEXT01.pdffulltext:print
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172917&type=printable
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318954
- https://doi.org/10.1371/journal.pone.0172917
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