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Somatic Ephrin Rece...
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Mathot, LucyUppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
(author)
Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer
- Article/chapterEnglish2017
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-319146
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-319146URI
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https://doi.org/10.1158/0008-5472.CAN-16-1921DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-142619URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The contribution of somatic mutations to metastasis of colorectal cancers is currently unknown. To find mutations involved in the colorectal cancer metastatic process, we performed deep mutational analysis of 676 genes in 107 stages II to IV primary colorectal cancer, of which half had metastasized. The mutation prevalence in the ephrin (EPH) family of tyrosine kinase receptors was 10-fold higher in primary tumors of metastatic colorectal than in nonmetastatic cases and preferentially occurred in stage III and IV tumors. Mutational analyses in situ confirmed expression of mutant EPH receptors. To enable functional studies of EPHB1 mutations, we demonstrated that DLD-1 colorectal cancer cells expressing EPHB1 form aggregates upon coculture with ephrin B1 expressing cells. When mutations in the fibronectin type III and kinase domains of EPHB1 were compared with wild-type EPHB1 in DLD-1 colorectal cancer cells, they decreased ephrin B1-induced compartmentalization. These observations provide a mechanistic link between EPHB receptor mutations and metastasis in colorectal cancer.
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Kundu, SnehangshuUppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)sneku918
(author)
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Ljungström, Viktor,1986-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi(Swepub:uu)viklj600
(author)
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Svedlund, JessicaStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)(Swepub:su)jesv4890
(author)
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Moens, LotteUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi,Johan Botling(Swepub:uu)lotmo617
(author)
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Adlerteg, TomUppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi(Swepub:uu)tomad175
(author)
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Falk-Sörqvist, ElinUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)elifa876
(author)
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Rendo, VerónicaUppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)verre103
(author)
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Bellomo, ClaudiaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)clabe897
(author)
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Mayrhofer, Markus,1981-Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab(Swepub:uu)marra353
(author)
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Cortina, Carme
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Sundström, MagnusUppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)magnsund
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Micke, PatrickUppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Patrick Micke(Swepub:uu)patmi676
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Botling, JohanUppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Johan Botling(Swepub:uu)johanbot
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Isaksson, AndersUppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab(Swepub:uu)andeisak
(author)
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Moustakas, AristidisUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)arimo287
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Batlle, Eduard
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Birgisson, HelgiUppsala universitet,Kolorektalkirurgi(Swepub:uu)hebir255
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Glimelius, BengtUppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)bengglim
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Nilsson, MatsStockholms universitet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Solna,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Uppsala University, Sweden(Swepub:su)matsn
(author)
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Sjöblom, TobiasUppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)tobisjob
(author)
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Uppsala universitetScience for Life Laboratory, SciLifeLab
(creator_code:org_t)
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In:Cancer Research77:7, s. 1730-17400008-54721538-7445
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Mathot, Lucy
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Kundu, Snehangsh ...
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Ljungström, Vikt ...
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Svedlund, Jessic ...
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Moens, Lotte
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Adlerteg, Tom
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Falk-Sörqvist, E ...
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Rendo, Verónica
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Bellomo, Claudia
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Mayrhofer, Marku ...
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Cortina, Carme
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Sundström, Magnu ...
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Micke, Patrick
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Botling, Johan
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Isaksson, Anders
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Moustakas, Arist ...
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Batlle, Eduard
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Birgisson, Helgi
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Glimelius, Bengt
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Nilsson, Mats
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Sjöblom, Tobias
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