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Evaluation of ECG-g...
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Hansson, Nils Henrik
(author)
Evaluation of ECG-gated [(11)C]acetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-04-19
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Springer Science and Business Media LLC,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-319488
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-319488URI
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https://doi.org/10.1007/s12350-015-0331-0DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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BACKGROUND: Noninvasive estimation of myocardial external efficiency (MEE) requires measurements of left ventricular (LV) oxygen consumption with [(11)C]acetate PET in addition to LV stroke volume and mass with cardiovascular magnetic resonance (CMR). Measuring LV geometry directly from ECG-gated [(11)C]acetate PET might enable MEE evaluation from a single PET scan. Therefore, we sought to establish the accuracy of measuring LV volumes, mass, and MEE directly from ECG-gated [(11)C]acetate PET.METHODS: Thirty-five subjects with aortic valve stenosis underwent ECG-gated [(11)C]acetate PET and CMR. List mode PET data were rebinned into 16-bin ECG-gated uptake images before measuring LV volumes and mass using commercial software and compared to CMR. Dynamic datasets were used for calculation of mean LV oxygen consumption and MEE.RESULTS: LV mass, volumes, and ejection fraction measured by CMR and PET correlated strongly (r = 0.86-0.92, P < .001 for all), but were underestimated by PET (P < .001 for all except ESV P = .79). PET-based MEE, corrected for bias, correlated fairly with PET/CMR-based MEE (r = 0.60, P < .001, bias -3 ± 21%, P = .56). PET-based MEE bias was strongly associated with LV wall thickness.CONCLUSIONS: Although analysis-related improvements in accuracy are recommended, LV geometry estimated from ECG-gated [(11)C]acetate PET correlate excellently with CMR and can indeed be used to evaluate MEE.
Subject headings and genre
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Myocardial external efficiency
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PET imaging
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magnetic resonance imaging
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metabolism: PET
Added entries (persons, corporate bodies, meetings, titles ...)
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Tolbod, Lars
(author)
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Harms, Johannes
(author)
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Wiggers, Henrik
(author)
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Kim, Won Yong
(author)
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Hansen, Esben
(author)
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Zaremba, Tomas
(author)
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Frøkiær, Jørgen
(author)
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Jakobsen, Steen
(author)
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Sörensen, JensUppsala universitet,Radiologi(Swepub:uu)jenssore
(author)
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Uppsala universitetRadiologi
(creator_code:org_t)
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In:Journal of Nuclear Cardiology: Springer Science and Business Media LLC23:4, s. 670-91071-35811532-6551
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Hansson, Nils He ...
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Tolbod, Lars
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Harms, Johannes
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Wiggers, Henrik
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Kim, Won Yong
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Hansen, Esben
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Zaremba, Tomas
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Frøkiær, Jørgen
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Jakobsen, Steen
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Sörensen, Jens
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Journal of Nucle ...
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Uppsala University