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Diffusion tensor im...
Diffusion tensor imaging and tractography of the white matter in normal aging : The rate-of-change differs between segments within tracts
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- Mårtensson, Johanna (author)
- Uppsala University,Uppsala universitet,Radiologi,Department of Surgical Sciences/Radiology, Uppsala University, Uppsala, Sweden
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- Lätt, J (author)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Åhs, Fredrik (author)
- Uppsala University,Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Fredriksson, Mats (author)
- Karolinska Institutet
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- Söderlund, Hedvig (author)
- Uppsala University,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Schiöth, Helgi B. (author)
- Karolinska Institutet,Uppsala universitet,Funktionell farmakologi,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Kok, J. (author)
- University of Groningen, University Medical Center Groningen, Department of Neurology, The Netherlands
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- Kremer, B. (author)
- University of Groningen, University Medical Center Groningen, Department of Neurology, The Netherlands
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- van Westen, Danielle (author)
- Department of Diagnostic Radiology, Skåne University Hospital, Lund, Sweden
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- Larsson, Elna-Marie (author)
- Uppsala University,Uppsala universitet,Radiologi,Department of Surgical Sciences/Radiology, Uppsala University, Uppsala, Sweden
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- Nilsson, M (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund University Bioimaging Center,MR Physics,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Magnetic Resonance Imaging. - : Elsevier BV. - 0730-725X .- 1873-5894. ; 45, s. 113-119
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Abstract
Subject headings
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- Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process is subject to spatial variations between tracts. The aim of this study was to investigate to what extent age-related variations also occur within tracts. DTI parameters were compared between segments of two white matter tracts, the cingulate bundle (CB) and the inferior fronto-occipital fasciculus (IFO), in 257 healthy individuals between 13 and 84years of age. Segments of the CB and the IFO were extracted and parameters for each segment were averaged across the hemispheres. The data was analysed as a function of age. Results show that age-related changes differ both between and within individual tracts. Different age trajectories were observed in all segments of the analysed tracts for all DTI parameters. In conclusion, aging does not affect white matter tracts uniformly but is regionally specific; both between and within white matter tracts.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Tractography
- Inferior fronto-occipital fasciculus
- Cingulum
- Aging
- White matter degeneration
- White matter tract
- Journal Article
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mårtensson, Joha ...
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Lätt, J
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Åhs, Fredrik
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Fredriksson, Mat ...
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Söderlund, Hedvi ...
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Schiöth, Helgi B ...
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show more...
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Kok, J.
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Kremer, B.
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van Westen, Dani ...
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Larsson, Elna-Ma ...
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Nilsson, M
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Magnetic Resonan ...
- By the university
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Uppsala University
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Mid Sweden University
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Karolinska Institutet
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Lund University