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Diffusion tensor imaging and tractography of the white matter in normal aging : The rate-of-change differs between segments within tracts

Mårtensson, Johanna (author)
Uppsala University,Uppsala universitet,Radiologi,Department of Surgical Sciences/Radiology, Uppsala University, Uppsala, Sweden
Lätt, J (author)
Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
Åhs, Fredrik (author)
Uppsala University,Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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Fredriksson, Mats (author)
Karolinska Institutet
Söderlund, Hedvig (author)
Uppsala University,Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
Schiöth, Helgi B. (author)
Karolinska Institutet,Uppsala universitet,Funktionell farmakologi,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Kok, J. (author)
University of Groningen, University Medical Center Groningen, Department of Neurology, The Netherlands
Kremer, B. (author)
University of Groningen, University Medical Center Groningen, Department of Neurology, The Netherlands
van Westen, Danielle (author)
Department of Diagnostic Radiology, Skåne University Hospital, Lund, Sweden
Larsson, Elna-Marie (author)
Uppsala University,Uppsala universitet,Radiologi,Department of Surgical Sciences/Radiology, Uppsala University, Uppsala, Sweden
Nilsson, M (author)
Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund University Bioimaging Center,MR Physics,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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 (creator_code:org_t)
Elsevier BV, 2018
2018
English.
In: Magnetic Resonance Imaging. - : Elsevier BV. - 0730-725X .- 1873-5894. ; 45, s. 113-119
Related links:
http://dx.doi.org/10...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process is subject to spatial variations between tracts. The aim of this study was to investigate to what extent age-related variations also occur within tracts. DTI parameters were compared between segments of two white matter tracts, the cingulate bundle (CB) and the inferior fronto-occipital fasciculus (IFO), in 257 healthy individuals between 13 and 84years of age. Segments of the CB and the IFO were extracted and parameters for each segment were averaged across the hemispheres. The data was analysed as a function of age. Results show that age-related changes differ both between and within individual tracts. Different age trajectories were observed in all segments of the analysed tracts for all DTI parameters. In conclusion, aging does not affect white matter tracts uniformly but is regionally specific; both between and within white matter tracts.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Tractography
Inferior fronto-occipital fasciculus
Cingulum
Aging
White matter degeneration
White matter tract
Journal Article

Publication and Content Type

ref (subject category)
art (subject category)

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