Sökning: onr:"swepub:oai:DiVA.org:uu-319602" >
Arterial spin label...
Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET.
-
- Fällmar, David (författare)
- Uppsala universitet,Radiologi
-
- Haller, Sven (författare)
- Uppsala universitet,Radiologi,Univ Med Ctr Freiburg, Dept Neuroradiol, Freiburg, Germany.; Univ Geneva, Fac Med, Geneva, Switzerland.; Affidea CDRC Ctr Diagnost Radiol Carouge, Carouge, Switzerland.
-
- Lilja, Johan (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Hermes Med Solut, Stockholm, Sweden
-
visa fler...
-
- Danfors, Torsten (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
-
- Kilander, Lena (författare)
- Uppsala universitet,Geriatrik
-
- Tolboom, Nelleke (författare)
- Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands
-
- Egger, Karl (författare)
- Univ Med Ctr Freiburg, Dept Neuroradiol, Freiburg, Germany
-
- Kellner, Elias (författare)
- Univ Freiburg, Dept Radiol, Med Ctr, Fac Med,Med Phys, Freiburg, Germany
-
- Croon, Philip M (författare)
- Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands
-
- Verfaillie, Sander C J (författare)
- Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands
-
- van Berckel, Bart N M (författare)
- Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands
-
- Ossenkoppele, Rik (författare)
- Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands
-
- Barkhof, Frederik (författare)
- Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Campus, Amsterdam, Netherlands.; UCL, Inst Neurol & Healthcare Engn, London, England.
-
- Larsson, Elna-Marie (författare)
- Uppsala universitet,Radiologi
-
visa färre...
-
(creator_code:org_t)
- 2017-04-03
- 2017
- Engelska.
-
Ingår i: European Radiology. - : Springer Science and Business Media LLC. - 0938-7994 .- 1432-1084. ; 27:10, s. 4237-4246
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://link.springe...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: Cerebral perfusion analysis based on arterial spin labeling (ASL) MRI has been proposed as an alternative to FDG-PET in patients with neurodegenerative disease. Z-maps show normal distribution values relating an image to a database of controls. They are routinely used for FDG-PET to demonstrate disease-specific patterns of hypometabolism at the individual level. This study aimed to compare the performance of Z-maps based on ASL to FDG-PET.METHODS: Data were combined from two separate sites, each cohort consisting of patients with Alzheimer's disease (n = 18 + 7), frontotemporal dementia (n = 12 + 8) and controls (n = 9 + 29). Subjects underwent pseudocontinuous ASL and FDG-PET. Z-maps were created for each subject and modality. Four experienced physicians visually assessed the 166 Z-maps in random order, blinded to modality and diagnosis.RESULTS: Discrimination of patients versus controls using ASL-based Z-maps yielded high specificity (84%) and positive predictive value (80%), but significantly lower sensitivity compared to FDG-PET-based Z-maps (53% vs. 96%, p < 0.001). Among true-positive cases, correct diagnoses were made in 76% (ASL) and 84% (FDG-PET) (p = 0.168).CONCLUSION: ASL-based Z-maps can be used for visual assessment of neurodegenerative dementia with high specificity and positive predictive value, but with inferior sensitivity compared to FDG-PET.KEY POINTS: • ASL-based Z-maps yielded high specificity and positive predictive value in neurodegenerative dementia. • ASL-based Z-maps had significantly lower sensitivity compared to FDG-PET-based Z-maps. • FDG-PET might be reserved for ASL-negative cases where clinical suspicion persists. • Findings were similar at two study sites.
Nyckelord
- 18F-FDG
- Arterial spin labeling MRI
- Dementia
- Neurodegenerative
- Visual assessment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Fällmar, David
-
Haller, Sven
-
Lilja, Johan
-
Danfors, Torsten
-
Kilander, Lena
-
Tolboom, Nelleke
-
visa fler...
-
Egger, Karl
-
Kellner, Elias
-
Croon, Philip M
-
Verfaillie, Sand ...
-
van Berckel, Bar ...
-
Ossenkoppele, Ri ...
-
Barkhof, Frederi ...
-
Larsson, Elna-Ma ...
-
visa färre...
- Artiklar i publikationen
-
European Radiolo ...
- Av lärosätet
-
Uppsala universitet