Search: onr:"swepub:oai:DiVA.org:uu-319935" >
Variability of phys...
Variability of physiological brain perfusion in healthy subjects : A systematic review of modifiers. Considerations for multi-center ASL studies
-
Clement, Patricia (author)
-
Mutsaerts, Henk-Jan (author)
-
Václavů, Lena (author)
-
show more...
-
Ghariq, Eidrees (author)
-
Pizzini, Francesca B (author)
-
Smits, Marion (author)
-
Acou, Marjan (author)
-
Jovicich, Jorge (author)
-
Vanninen, Ritva (author)
-
Kononen, Mervi (author)
-
Wiest, Roland (author)
-
Rostrup, Egill (author)
-
Bastos-Leite, António J (author)
-
- Larsson, Elna-Marie (author)
- Uppsala universitet,Radiologi
-
Achten, Eric (author)
-
show less...
-
(creator_code:org_t)
- 2018
- 2018
- English.
-
In: Journal of Cerebral Blood Flow and Metabolism. - 0271-678X .- 1559-7016. ; 38:9, s. 1418-1437
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Quantitative measurements of brain perfusion are influenced by perfusion-modifiers. Standardization of measurement conditions and correction for important modifiers is essential to improve accuracy and to facilitate the interpretation of perfusion-derived parameters. An extensive literature search was carried out for factors influencing quantitative measurements of perfusion in the human brain unrelated to medication use. A total of 58 perfusion modifiers were categorized into four groups. Several factors (e.g., caffeine, aging, and blood gases) were found to induce a considerable effect on brain perfusion that was consistent across different studies; for other factors, the modifying effect was found to be debatable, due to contradictory results or lack of evidence. Using the results of this review, we propose a standard operating procedure, based on practices already implemented in several research centers. Also, a theory of ' deep MRI physiotyping' is inferred from the combined knowledge of factors influencing brain perfusion as a strategy to reduce variance by taking both personal information and the presence or absence of perfusion modifiers into account. We hypothesize that this will allow to personalize the concept of normality, as well as to reach more rigorous and earlier diagnoses of brain disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Arterial spin labeling
- cerebral perfusion
- deep MRI physiotyping
- physiology
- variability
Publication and Content Type
- ref (subject category)
- for (subject category)
Find in a library
To the university's database
- By the author/editor
-
Clement, Patrici ...
-
Mutsaerts, Henk- ...
-
Václavů, Lena
-
Ghariq, Eidrees
-
Pizzini, Frances ...
-
Smits, Marion
-
show more...
-
Acou, Marjan
-
Jovicich, Jorge
-
Vanninen, Ritva
-
Kononen, Mervi
-
Wiest, Roland
-
Rostrup, Egill
-
Bastos-Leite, An ...
-
Larsson, Elna-Ma ...
-
Achten, Eric
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Radiology Nuclea ...
- Articles in the publication
-
Journal of Cereb ...
- By the university
-
Uppsala University