Search: onr:"swepub:oai:DiVA.org:uu-320276" >
Human papillomaviru...
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Sivars, LarsKarolinska Institutet
(author)
Human papillomavirus DNA detection in fine-needle aspirates as indicator of human papillomavirus-positive oropharyngeal squamous cell carcinoma : A prospective study
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2016-11-29
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Wiley,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-320276
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320276URI
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https://doi.org/10.1002/hed.24641DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135492038URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background. Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) has a better outcome than most head neck squamous cell carcinomas (HNSCCs) and an HPV-positive lymph node metastasis likely has an HPV-positive oropharyngeal SCC origin. Determining HPV-status in cervical lymph nodes by fine-needle aspiration cytology (FNAC) may be useful for diagnosis. Methods. FNACs from 66 patients with neck masses were prospectively examined for HPV DNA and HPV16 mRNA by a polymerase chain reaction (PCR)-based assay, and the data correlated to diagnosis and HPV-status obtained from histopathological specimens. Results. Aspirates from 17 of 66 patients, later diagnosed with HPV-positive oropharyngeal SCC, were HPV16 DNA-positive. HPV16 mRNA was detected in all cases with extractable RNA. All remaining FNACs, including 18 branchial cleft cysts, were HPV DNA-negative. HPV DNA status in the aspirates showed perfect concordance with corresponding biopsies. Conclusion. HPV16 DNA detection in fine-needle aspirations from neck masses is reliable and HPV16 DNA in a metastasis is a strong indicator of an HPV-positive oropharyngeal SCC.
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Landin, DavidKarolinska Institutet
(author)
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Haeggblom, LinneaKarolinska Institutet
(author)
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Tertipis, NikolaosKarolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
(author)
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Grun, NathalieKarolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
(author)
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Bersani, CinziaKarolinska Institutet
(author)
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Marklund, LindaKarolinska Institutet
(author)
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Ghaderi, MehranKarolinska Institutet
(author)
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Nasman, AndersKarolinska Institutet
(author)
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Ramqvist, TorbjornKarolinska Institutet
(author)
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Nordfors, CeciliaKarolinska Institutet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
(author)
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Munck-Wikland, EvaKarolinska Institutet
(author)
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Tani, EdneiaKarolinska Institutet
(author)
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Dalianis, TinaKarolinska Institutet
(author)
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Karolinska InstitutetKarolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
(creator_code:org_t)
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In:Head and Neck: Wiley39:3, s. 419-4261043-30741097-0347
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Sivars, Lars
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Landin, David
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Haeggblom, Linne ...
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Tertipis, Nikola ...
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Grun, Nathalie
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Bersani, Cinzia
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Marklund, Linda
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Ghaderi, Mehran
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Nasman, Anders
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Nordfors, Cecili ...
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Munck-Wikland, E ...
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Tani, Edneia
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Dalianis, Tina
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Head and Neck
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Uppsala University
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Karolinska Institutet