DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites

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Bergmann, Anke K.Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany.;Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Pediat, Campus Kiel, Kiel, Germany. (author)

DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites

Article/chapterEnglish2017

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2016-10-27
Wiley,2017
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LIBRIS-ID:oai:DiVA.org:uu-320291
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320291URI
https://doi.org/10.1002/pbc.26251DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Deregulation of the epigenome is an important pathogenetic mechanism in acute lymphoblastic leukemia (ALL) with lysine (K)-specific methyltransferase 2A rearrangement (KMT2Ar). We performed array-based DNA methylation profiling of KMT2Ar ALL cells from 26 children in comparison to normal B-cell precursors. Significant changes in DNA methylation in KMT2Ar ALL were identified in 2,545 CpG loci, influenced by age and the translocation partners AFF1 and MLLT1. In KMT2Ar ALL, DNA methylation loss was enriched at enhancers and for certain transcription factor binding sites such as BCL11A, EBF, and MEF2A. In summary, DNA methylation changes in KMT2Ar ALL target enhancers, genes involved in leukemogenesis and normal hematopoiesis, as well as transcription factor networks.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
acute lymphoblastic leukemia
DNA methylation
enhancer hypomethylation
infant ALL
KMT2A rearrangements

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Castellano, GiancarloUniv Barcelona, Inst Biomed August Pi Sunyer IDIBAPS, Dept Analomia Palol & Microbiol, Dept Farmacol & Microbiol, Barcelona, Spain. (author)
Alten, JuliaChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Pediat, Campus Kiel, Kiel, Germany. (author)
Ammerpohl, OleChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany. (author)
Kolarova, JuliaChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany.;Univ Ulm, Univ Med Ctr Ulm, Inst Human Genet, Ulm, Germany. (author)
Nordlund, JessicaUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)jesno775 (author)
Martin-Subero, Jose IgnacioUniv Barcelona, Inst Biomed August Pi Sunyer IDIBAPS, Dept Analomia Palol & Microbiol, Dept Farmacol & Microbiol, Barcelona, Spain. (author)
Schrappe, MartinChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Pediat, Campus Kiel, Kiel, Germany. (author)
Siebert, ReinerChristian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany.;Univ Ulm, Univ Med Ctr Ulm, Inst Human Genet, Ulm, Germany. (author)
Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel,Schwanenweg 24, Kiel, Germany.;Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Pediat, Campus Kiel, Kiel, Germany.Univ Barcelona, Inst Biomed August Pi Sunyer IDIBAPS, Dept Analomia Palol & Microbiol, Dept Farmacol & Microbiol, Barcelona, Spain. (creator_code:org_t)

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In:Pediatric Blood & Cancer: Wiley64:31545-50091545-5017

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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