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Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation

Han, Hongya (author)
Karolinska Institutet
Liang, Xiuming (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
Ekberg, Monica (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
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Kritikou, Joanna S. (author)
Karolinska Institutet
Brunnstrom, Asa (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
Pelcman, Benjamin (author)
Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
Matl, Maria (author)
Karolinska Institutet
Miao, Xinyan (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Clin Pharmacol Grp, Stockholm, Sweden.
Andersson, Margareta (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
Yuan, Xiaotian (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
Schain, Frida (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
Parvin, Selina (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
Melin, Eva (author)
Karolinska Institutet
Sjoberg, Jan (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
Xu, Dawei (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
Westerberg, Lisa S. (author)
Karolinska Institutet
Bjorkholm, Magnus (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
Claesson, Hans-Erik (author)
Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden.
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Karolinska Institutet Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Med,Div Hematol, Stockholm, Sweden (creator_code:org_t)
FEDERATION AMER SOC EXP BIOL, 2017
2017
English.
In: The FASEB Journal. - : FEDERATION AMER SOC EXP BIOL. - 0892-6638 .- 1530-6860. ; 31:2, s. 491-504
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https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Dendritic cells (DCs) involved in proinflammatory immune responses derive mainly from peripheral monocytes, and the cells subsequently mature and migrate into the inflammatory micromilieu. Here we report that suppressing of 15-lipoxygenase-1 led to a substantial reduction in DC spreading and podosome formation in vitro. The surface expression of CD83 was significantly lower in both sh-15-lipoxygenase-1 (15-LOX-1)-transduced cells and DCs cultivated in the presence of a novel specific 15-LOX-1 inhibitor. The T-cell response against tetanus-pulsed DCs was only affected to a minor extent on inhibition of 15-LOX-1. In contrast, endocytosis and migration ability of DCs were significantly suppressed on 15-LOX-1 inhibition. The expression of 15-LOX-1 in DCs was also demonstrated in affected human skin in atopic and contact dermatitis, showing that the enzyme is indeed expressed in inflammatory diseases in vivo. This study demonstrated that inhibiting 15-LOX-1 led to an impaired podosome formation in DCs, and consequently suppressed antigen uptake and migration capacity. These results indicated that 15-LOX-1 is a potential target for inhibiting the trafficking of DCs to lymphoid organs and inflamed tissues and decreasing the inflammatory response attenuating symptoms of certain immunologic and inflammatory disorders such as dermatitis.-Han, H., Liang, X., Ekberg, M., Kritikou, J. S., Brunnstro " m, angstrom., Pelcman, B., Matl, M., Miao, X., Andersson, M., Yuan, X., Schain, F., Parvin, S., Melin, E., Sjoberg, J., Xu, D., Westerberg, L. S., Bjorkholm, M., Claesson, H.- E. Human 15-lipoxygenase- 1 is a regulator of dendritic-cell spreading and podosome formation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

arachidonic acid
cell migration
dermatitis
endocytosis

Publication and Content Type

ref (subject category)
art (subject category)

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