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GvHD after umbilica...
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Chen, Y-BMassachusetts Gen Hosp, Yawkey 9E 9052 55 Fruit St, Boston, MA 02114 USA.
(author)
GvHD after umbilical cord blood transplantation for acute leukemia : an analysis of risk factors and effect on outcomes
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2016-12-12
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NATURE PUBLISHING GROUP,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-320834
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320834URI
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https://doi.org/10.1038/bmt.2016.265DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135472726URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Using the Center for International Blood and Marrow Transplant Research (CIBMTR) registry, we analyzed 1404 umbilical cord blood transplantation (UCBT) patients (single (>= 18 years) = 810, double (< 18 years) = 594) with acute leukemia to define the incidence of acute GvHD (aGvHD) and chronic GvHD (cGvHD), analyze clinical risk factors and investigate outcomes. After single UCBT, 100-day incidence of grade II-IV aGvHD was 39% (95% confidence interval (CI), 36-43%), grade III-IV aGvHD was 18% (95% CI, 15-20%) and 1-year cGvHD was 27% (95% CI, 24-30%). After double UCBT, 100-day incidence of grade II-IV aGvHD was 45% (95% CI, 41-49%), grade III-IV aGvHD was 22% (95% CI, 19-26%) and 1-year cGvHD was 26% (95% CI, 22-29%). For single UCBT, multivariate analysis showed that absence of antithymocyte globulin (ATG) was associated with aGvHD, whereas prior aGvHD was associated with cGvHD. For double UCBT, absence of ATG and myeloablative conditioning were associated with aGvHD, whereas prior aGvHD predicted for cGvHD. Grade III-IV aGvHD led to worse survival, whereas cGvHD had no significant effect on disease-free or overall survival. GvHD is prevalent after UCBT with severe aGvHD leading to higher mortality. Future research in UCBT should prioritize prevention of GvHD.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wang, T.Med Coll Wisconsin, Ctr Int Blood, Marrow Transplant Res, Dept Med, Milwaukee, WI USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Soc, Milwaukee, WI USA.
(author)
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Hemmer, M. T.Med Coll Wisconsin, Ctr Int Blood, Marrow Transplant Res, Dept Med, Milwaukee, WI USA.
(author)
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Brady, C.Natl Marrow Donor Program Be Match, Ctr Int Blood, Marrow Transplant Res, Minneapolis, MN USA.
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Couriel, D. R.Marrow Transplant Program, Utah Blood, Salt Lake City, UT USA.
(author)
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Alousi, A.Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Stem Cell Transplantat, Houston, TX 77030 USA.
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Pidala, J.H Lee Moffitt Canc Ctr & Res Inst, Res Inst, Tampa, FL USA.
(author)
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Urbano-Ispizua, A.Univ Barcelona, IDIBAPS, Hosp Clin, Barcelona, Spain.;Univ Barcelona, Inst Res Josep Carreras, Dept Hematol, Hosp Clin, Barcelona, Spain.
(author)
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Choi, S. W.Univ Michigan, Ann Arbor, MI 48109 USA.
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Nishihori, T.H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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Teshima, T.Univ Hosp, Fukuoka, Japan.
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Inamoto, Y.Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.
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Wirk, B.Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
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Marks, D. I.Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England.
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Abdel-Azim, H.Univ So Calif, Keck Sch Med, Marrow Transplantat, Div Hematol Oncol & Blood, Los Angeles, CA 90033 USA.
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Lehmann, L.Boston Childrens Hosp, Dana Farber Canc Inst, Boston, MA USA.
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Yu, L.Louisiana State Univ, Med Ctr, Div Hematol Oncol, Childrens Hosp,Ctr Canc & Blood Disorders,HSC, New Orleans, LA USA.
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Bitan, M.Tel Aviv Sourasky Med Ctr, Tel Aviv, Dept Pediat Hematol Oncol, Tel Aviv, Israel.
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Cairo, M. S.New York Med Coll, Div Pediat Hematol Oncol, Stem Cell Transplantat, Dept Pediat, Valhalla, NY USA.
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Qayed, M.Emory Univ, Sch Med, Dept Pediat, Atlanta, GA, Australia.
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Salit, R.Fred Hutchinson Canc Res Ctr, Seattle, WA USA.
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Gale, R. P.Imperial Coll London, Hematol Res Ctr, Div Expt Med, Dept Med, London, England.
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Martino, R.Hosp Santa Creu St Pau, Div Clin Hematol, Barcelona, Spain.
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Jaglowski, S.Ohio State Univ, Med Ctr, Div Hematol, Columbus, OH 43210 USA.
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Bajel, A.Royal Melbourne Hosp City Campus, Melbourne, Australia.
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Savani, B.Vanderbilt Univ, Med Ctr, Div Hematol Oncol, Dept Med, Nashville, TN USA.
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Frangoul, H.Vanderbilt Univ, Sch Med, Div Hematol Oncol, Dept Pediat, Nashville, TN USA.
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Lewis, I. D.Royal Adelaide Hosp, Haematol & Bone Marrow Transplant Unit, Adelaide, SA, Australia.
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Storek, J.Univ Calgary, Dept Med, Calgary, AB, Canada.
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Askar, M.Baylor Univ, Med Ctr, Dallas, TX USA.
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Kharfan-Dabaja, M. A.H Lee Mofitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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Aljurf, M.King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
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Ringden, O.Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Div Therapeut Immunol, Dept Lab Med, Stockholm, Sweden.
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Reshef, R.Columbia Univ, Med Ctr, Blood & Marrow Transplantat Program, Columbia Ctr Translat Immunol, New York, NY USA.
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Olsson, R. F.Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Div Therapeut Immunol, Dept Lab Med, Stockholm, Sweden.
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Hashmi, S.Mayo Clin Rochester, Rochester, MN USA.
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Seo, S.Nat Canc Res Ctr, East Hosp, Kashiwa, Chiba, Japan.
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Spitzer, T. R.
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MacMillan, M. L.Univ Minnesota, Med Ctr, Minneapolis, MN USA.
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Lazaryan, A.Univ Minnesota, Med Ctr, Div Hematol Oncol, Dept Med, Minneapolis, MN USA.
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Spellman, S. R.
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Arora, M.
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Cutler, C. S.Dana Farber Canc Inst, Ctr Hematol Oncol, Dept Med Oncol, Boston, MA USA.
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Massachusetts Gen Hosp, Yawkey 9E 9052 55 Fruit St, Boston, MA 02114 USA.Med Coll Wisconsin, Ctr Int Blood, Marrow Transplant Res, Dept Med, Milwaukee, WI USA.;Med Coll Wisconsin, Div Biostat, Inst Hlth & Soc, Milwaukee, WI USA.
(creator_code:org_t)
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In:Bone Marrow Transplantation: NATURE PUBLISHING GROUP52:3, s. 400-4080268-33691476-5365
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- By the author/editor
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Chen, Y-B
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Wang, T.
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Hemmer, M. T.
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Brady, C.
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Couriel, D. R.
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Alousi, A.
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show more...
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Pidala, J.
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Urbano-Ispizua, ...
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Choi, S. W.
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Nishihori, T.
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Teshima, T.
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Inamoto, Y.
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Wirk, B.
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Marks, D. I.
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Abdel-Azim, H.
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Lehmann, L.
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Yu, L.
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Bitan, M.
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Cairo, M. S.
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Qayed, M.
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Salit, R.
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Gale, R. P.
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Martino, R.
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Jaglowski, S.
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Bajel, A.
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Savani, B.
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Frangoul, H.
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Lewis, I. D.
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Storek, J.
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Askar, M.
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Kharfan-Dabaja, ...
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Aljurf, M.
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Ringden, O.
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Reshef, R.
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Olsson, R. F.
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Hashmi, S.
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Seo, S.
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Spitzer, T. R.
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MacMillan, M. L.
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Lazaryan, A.
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Spellman, S. R.
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Arora, M.
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Cutler, C. S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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Bone Marrow Tran ...
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Uppsala University
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Karolinska Institutet