Search: onr:"swepub:oai:DiVA.org:uu-320987" >
Enhanced release of...
Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers
-
- Yang, Jiaojiao (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials
-
- Alvebratt, Caroline (author)
- Uppsala universitet,Institutionen för farmaci
-
- Zhang, Peng (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials
-
show more...
-
- Zardán Gómez de la Torre, Teresa (author)
- Uppsala universitet,Nanoteknologi och funktionella material,Nanoteknologi och funktionella material, Nanotechnology and Functional Materials
-
- Strömme, Maria, 1970- (author)
- Uppsala universitet,Nanoteknologi och funktionella material
-
- Bergström, Christel, 1973- (author)
- Uppsala universitet,Institutionen för farmaci
-
- Welch, Ken, 1968- (author)
- Uppsala universitet,Nanoteknologi och funktionella material
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
-
In: International Journal of Pharmaceutics. - : Elsevier BV. - 0378-5173 .- 1873-3476. ; 525:1, s. 183-190
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The need to combat poor water solubility has increased interest in supersaturating drug delivery systems. In this study, amorphous mesoporous magnesium carbonate (MMC) was used as a drug carrier to achieve supersaturation of tolfenamic acid and rimonabant, two drug compounds with low aqueous solubility. The potential synergy between MMC and hydroxypropyl methylcellulose (HPMC), a polymer commonly included as a precipitation inhibitor in drug delivery systems, was explored with the aim of extending the time that high supersaturation levels were maintained. Release was studied under physiological conditions using USP-2 dissolution baths. A new small-scale method was developed to enable measurement of the initial drug release occurring when the MMC is immersed in the water phase. It was shown that MMC and HPMC together resulted in significant supersaturation and that the polymer enabled both the achievement of a higher API concentration and extension of the supersaturation period. The new small-scale release method showed that the release was linearly increasing with the dose and that similar release rates were observed for the two model compounds. It was hence concluded that the MMC release was diffusion limited for the compounds explored.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Keyword
- Magnesium carbonate
- Mesoporous
- Hydroxypropyl methylcellulose
- Tolfenamic acid
- Rimonabant
- Supersaturation
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
- Engineering Science with specialization in Nanotechnology and Functional Materials
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database