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Amyloid tracers bin...
Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease
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- Ni, Ruiqing (author)
- Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Stockholm, Sweden.
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- Gillberg, Per-Goran (author)
- Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Stockholm, Sweden.
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- Bogdanovic, Nenad (author)
- Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Univ Oslo, Dept Geriatr Med, Oslo, Norway.
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- Viitanen, Matti (author)
- Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Stockholm, Sweden.
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- Myllykangas, Liisa (author)
- Univ Helsinki, Dept Pathol, Helsinki, Finland.
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- Nennesmo, Inger (author)
- Karolinska Institutet,Karolinska Univ Hosp Huddinge, Dept Lab Med, Div Pathol, Stockholm, Sweden.
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- Långström, Bengt (author)
- Uppsala universitet,Organisk kemi
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- Nordberg, Agneta (author)
- Karolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Stockholm, Sweden (creator_code:org_t)
- 2016-09-28
- 2017
- English.
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In: Alzheimer's & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 13:4, s. 419-430
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Abstract
Subject headings
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- Introduction: Amyloid imaging has been integrated into diagnostic criteria for Alzheimer's disease (AD). How amyloid tracers binding differ for different tracer structures and amyloid-beta aggregates in autosomal dominant AD (ADAD) and sporadic AD is unclear. Methods: Binding properties of different amyloid tracers were examined in brain homogenates from six ADAD with APPswe, PS1 M146V, and PS1 E Delta 9 mutations, 13 sporadic AD, and 14 control cases. Results: H-3-PIB, H-3-florbetaben, H-3-AZD2184, and BTA-1 shared a high-and a varying low-affinity binding site in the frontal cortex of sporadic AD. AZD2184 detected another binding site (affinity 33 nM) in the frontal cortex of ADAD. The H-3-AZD2184 and H-3-PIB binding were significantly higher in the striatum of ADAD compared to sporadic AD and control. Polyphenol resveratrol showed strongest inhibition on H-3-AZD84 binding followed by H-3-florbetaben and minimal on H-3-PIB. Discussion: This study implies amyloid tracers of different structures detect different sites on amyloid-beta fibrils or conformations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- Amyloid-beta
- Autosomal dominant Alzheimer's disease
- Positron emission tomography
- Resveratrol
- Pittsburgh compound B
- AZD2184
- Florbetaben
Publication and Content Type
- ref (subject category)
- art (subject category)
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