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  • Ni, RuiqingKarolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Stockholm, Sweden. (author)

Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-09-28
  • Wiley,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-321327
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-321327URI
  • https://doi.org/10.1016/j.jalz.2016.08.006DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135541559URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Introduction: Amyloid imaging has been integrated into diagnostic criteria for Alzheimer's disease (AD). How amyloid tracers binding differ for different tracer structures and amyloid-beta aggregates in autosomal dominant AD (ADAD) and sporadic AD is unclear. Methods: Binding properties of different amyloid tracers were examined in brain homogenates from six ADAD with APPswe, PS1 M146V, and PS1 E Delta 9 mutations, 13 sporadic AD, and 14 control cases. Results: H-3-PIB, H-3-florbetaben, H-3-AZD2184, and BTA-1 shared a high-and a varying low-affinity binding site in the frontal cortex of sporadic AD. AZD2184 detected another binding site (affinity 33 nM) in the frontal cortex of ADAD. The H-3-AZD2184 and H-3-PIB binding were significantly higher in the striatum of ADAD compared to sporadic AD and control. Polyphenol resveratrol showed strongest inhibition on H-3-AZD84 binding followed by H-3-florbetaben and minimal on H-3-PIB. Discussion: This study implies amyloid tracers of different structures detect different sites on amyloid-beta fibrils or conformations.

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  • Gillberg, Per-GoranKarolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Stockholm, Sweden. (author)
  • Bogdanovic, NenadKarolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Univ Oslo, Dept Geriatr Med, Oslo, Norway. (author)
  • Viitanen, MattiKarolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Stockholm, Sweden. (author)
  • Myllykangas, LiisaUniv Helsinki, Dept Pathol, Helsinki, Finland. (author)
  • Nennesmo, IngerKarolinska Institutet,Karolinska Univ Hosp Huddinge, Dept Lab Med, Div Pathol, Stockholm, Sweden. (author)
  • Långström, BengtUppsala universitet,Organisk kemi(Swepub:uu)benglang (author)
  • Nordberg, AgnetaKarolinska Institutet,Karolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Stockholm, Sweden. (author)
  • Karolinska InstitutetKarolinska Inst, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Div Translat Alzheimer Neurobiol, Stockholm, Sweden. (creator_code:org_t)

Related titles

  • In:Alzheimer's & Dementia: Wiley13:4, s. 419-4301552-52601552-5279

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