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Use of Swedish smok...
Use of Swedish smokeless tobacco (snus) and the risk of Type 2 diabetes and latent autoimmune diabetes of adulthood (LADA)
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- Rasouli, B. (author)
- Karolinska Institutet
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- Andersson, T. (author)
- Karolinska Institutet
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- Carlsson, P-O (author)
- Uppsala universitet,Transplantation och regenerativ medicin
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- Grill, V. (author)
- Norwegian Univ Sci & Technol, NTNU Inst Canc Res & Mol Med, Trondheim, Norway.;Univ Trondheim Hosp, Dept Endocrinol, Trondheim, Norway.
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- Groop, L. (author)
- Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
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- Martinell, Mats, 1971- (author)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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- Midthjell, K. (author)
- Norwegian Univ Sci & Technol, Dept Community Med & Gen Practice, HUNT Res Ctr, Levanger, Norway.
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- Storm, P. (author)
- Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
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- Tuomi, T. (author)
- Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland.;Univ Helsinki, Res Program Diabet & Obes, Helsinki, Finland.
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- Carlsson, S. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-07-31
- 2017
- English.
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In: Diabetic Medicine. - : Wiley. - 0742-3071 .- 1464-5491. ; 34:4, s. 514-521
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- AimsIt has been suggested that moist snuff (snus), a smokeless tobacco product that is high in nicotine and widespread in Scandinavia, increases the risk of Type 2 diabetes. Previous studies are however few, contradictory and, with regard to autoimmune diabetes, lacking. Our aim was to study the association between snus use and the risk of Type 2 diabetes and latent autoimmune diabetes of adulthood (LADA). MethodAnalyses were based on incident cases (Type 2 diabetes, n = 724; LADA, n = 200) and population-based controls (n = 699) from a Swedish case-control study. Additional analyses were performed on cross-sectional data from the Norwegian HUNT study (n = 21 473) with 829 prevalent cases of Type 2 diabetes. Odds ratios (OR) were estimated adjusted for age, BMI family history of diabetes and smoking. Only men were included. ResultsNo association between snus use and Type 2 diabetes or LADA was seen in the Swedish data. For Type 2 diabetes, the OR for > 10 box-years was 1.00 [95% confidence interval (CI), 0.47 to 2.11] and for LADA 1.01 (95% CI, 0.45 to 2.29). Similarly, in HUNT, the OR for Type 2 diabetes in ever-users was estimated at 0.91 (95% CI, 0.75 to 1.10) and in heavy users at 0.92 (95% CI, 0.46 to 1.83). ConclusionThe risk of Type 2 diabetes and LADA is unrelated to the use of snus, despite its high nicotine content. This opens the possibility of the increased risk of Type 2 diabetes seen in smokers may not be attributed to nicotine, but to other substances in tobacco smoke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Rasouli, B.
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Andersson, T.
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Carlsson, P-O
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Grill, V.
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Groop, L.
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Martinell, Mats, ...
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show more...
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Midthjell, K.
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Storm, P.
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Tuomi, T.
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Carlsson, S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetic Medicin ...
- By the university
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Uppsala University
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Karolinska Institutet