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Guanine Can Direct Binding Specificity of Ru-dipyridophenazine (dppz) Complexes to DNA through Steric Effects

Hall, James P. (author)
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England.;Diamond Light Source, Harwell Sci & Innovat Campus,Fermi Ave, Didcot OX11 0QX, Oxon, England.,Diamond Light Source,University of Reading
Gurung, Sarah P. (author)
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England.;Diamond Light Source, Harwell Sci & Innovat Campus,Fermi Ave, Didcot OX11 0QX, Oxon, England.,Diamond Light Source,University of Reading
Henle, Jessica (author)
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England.,University of Reading
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Poidl, Patrick (author)
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England.
Andersson, Johanna (author)
Uppsala universitet,Institutionen för kemi - BMC,Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology
Lincoln, Per, 1958 (author)
Chalmers, Dept Chem & Chem Engn, S-41296 Gothenburg, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology
Winter, Graeme (author)
Diamond Light Source, Harwell Sci & Innovat Campus,Fermi Ave, Didcot OX11 0QX, Oxon, England.
Sorensen, Thomas (author)
Diamond Light Source, Harwell Sci & Innovat Campus,Fermi Ave, Didcot OX11 0QX, Oxon, England.
Cardin, David J. (author)
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England.,University of Reading
Brazier, John A. (author)
Univ Reading, Dept Pharm, Reading RG6 6AD, Berks, England.,University of Reading
Cardin, Christine J. (author)
Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England.,University of Reading
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Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England;Diamond Light Source, Harwell Sci & Innovat Campus,Fermi Ave, Didcot OX11 0QX, Oxon, England. Diamond Light Source (creator_code:org_t)
2017-02-06
2017
English.
In: Chemistry - A European Journal. - : Wiley-VCH Verlagsgesellschaft. - 0947-6539 .- 1521-3765. ; 23:21, s. 4981-4985
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • X-ray crystal structures of three -[Ru(L)(2)dppz](2+) complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5-CG-3 step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2 group, in contrast to symmetrical intercalation previously observed at 5-TA-3 sites. This result suggests that canted intercalation is preferred at 5-CG-3 sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5-CG-3 step could give rise to a longer luminescence lifetime than canted intercalation.

Subject headings

NATURVETENSKAP  -- Kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Keyword

DNA
DNA structures
nucleic acids
structural biology

Publication and Content Type

ref (subject category)
art (subject category)

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