Hypermobile Ehlers-Danlos Syndrome (a.k.a. Ehlers-Danlos Syndrome Type III and Ehlers-Danlos Syndrome Hypermobility Type): Clinical Description and Natural History

Hypermobile Ehlers-Danlos Syndrome (a.k.a. Ehlers-Danlos Syndrome Type III and Ehlers-Danlos Syndrome Hypermobility Type) : Clinical Description and Natural History

The hypermobile type of Ehlers-Danlos syndrome (hEDS) is likely the most common hereditary disorder of connective tissue. It has been described largely in those with musculoskeletal complaints including joint hypermobility, joint subluxations/dislocations, as well as skin and soft tissue manifestations. Many patients report activity-related pain and some go on to have daily pain. Two undifferentiated syndromes have been used to describe these manifestations-joint hypermobility syndrome and hEDS. Both are clinical diagnoses in the absence of other causation. Current medical literature further complicates differentiation and describes multiple associated symptoms and disorders. The current EDS nosology combines these two entities into the hypermobile type of EDS. Herein, we review and summarize the literature as a better clinical description of this type of connective tissue disorder.

Castori, Marco (author)
Berglund, BrittaUppsala universitet,Institutionen för folkhälso- och vårdvetenskap (author)
Cohen, HelenRoyal Natl Orthopaed Hosp, Dept Rheumatol, Brockley Hill, Stanmore, Middx, England. (author)
Grahame, RodneyUCL, Ctr Rheumatol, London, England.;Hosp St John & St Elizabeth, Hypermobil Unit, London, England. (author)
Kazkaz, HanadiUniv Coll Hosp, Rheumatol Dept, London, England. (author)
Levy, HowardJohns Hopkins Univ, Baltimore, MD 21218 USA. (author)
Advocate Childrens Hosp, Clin Genet, Park Ridge, IL USA.Institutionen för folkhälso- och vårdvetenskap (creator_code:org_t)

In:American Journal of Medical Genetics. Part C, Seminars in Medical Genetics: WILEY175:1, s. 48-691552-48681552-4876

By the author/editor: Tinkle, Brad; Castori, Marco; Berglund, Britta; Cohen, Helen; Grahame, Rodney; Kazkaz, Hanadi; show more...; Levy, Howard; show less...

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