Sökning: onr:"swepub:oai:DiVA.org:uu-325672" > The EU-AIMS Longitu...
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000 | 06923naa a2201213 4500 | |
001 | oai:DiVA.org:uu-325672 | |
003 | SwePub | |
008 | 170627s2017 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:136090653 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3256722 URI |
024 | 7 | a https://doi.org/10.1186/s13229-017-0145-92 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1360906532 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Charman, Tony4 aut |
245 | 1 0 | a The EU-AIMS Longitudinal European Autism Project (LEAP) :b clinical characterisation. |
264 | c 2017-06-23 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers.METHODS: From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms.RESULTS: The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females.CONCLUSIONS: The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
653 | a Age | |
653 | a Autism | |
653 | a Autism spectrum disorder | |
653 | a Behaviours | |
653 | a Heterogeneity | |
653 | a IQ | |
653 | a Phenotype | |
653 | a Sex | |
700 | 1 | a Loth, Eva4 aut |
700 | 1 | a Tillmann, Julian4 aut |
700 | 1 | a Crawley, Daisy4 aut |
700 | 1 | a Wooldridge, Caroline4 aut |
700 | 1 | a Goyard, David4 aut |
700 | 1 | a Ahmad, Jumana4 aut |
700 | 1 | a Auyeung, Bonnie4 aut |
700 | 1 | a Ambrosino, Sara4 aut |
700 | 1 | a Banaschewski, Tobias4 aut |
700 | 1 | a Baron-Cohen, Simon4 aut |
700 | 1 | a Baumeister, Sarah4 aut |
700 | 1 | a Beckmann, Christian4 aut |
700 | 1 | a Bölte, Svenu Karolinska Institutet4 aut |
700 | 1 | a Bourgeron, Thomas4 aut |
700 | 1 | a Bours, Carsten4 aut |
700 | 1 | a Brammer, Michael4 aut |
700 | 1 | a Brandeis, Daniel4 aut |
700 | 1 | a Brogna, Claudia4 aut |
700 | 1 | a de Bruijn, Yvette4 aut |
700 | 1 | a Chakrabarti, Bhismadev4 aut |
700 | 1 | a Cornelissen, Ineke4 aut |
700 | 1 | a Acqua, Flavio Dell'4 aut |
700 | 1 | a Dumas, Guillaume4 aut |
700 | 1 | a Durston, Sarah4 aut |
700 | 1 | a Ecker, Christine4 aut |
700 | 1 | a Faulkner, Jessica4 aut |
700 | 1 | a Frouin, Vincent4 aut |
700 | 1 | a Garcés, Pilar4 aut |
700 | 1 | a Ham, Lindsay4 aut |
700 | 1 | a Hayward, Hannah4 aut |
700 | 1 | a Hipp, Joerg4 aut |
700 | 1 | a Holt, Rosemary J4 aut |
700 | 1 | a Isaksson, Johanu Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst KIND, Ctr Neurodev Disorders, Stockholm, Sweden4 aut0 (Swepub:uu)johis856 |
700 | 1 | a Johnson, Mark H4 aut |
700 | 1 | a Jones, Emily J H4 aut |
700 | 1 | a Kundu, Prantik4 aut |
700 | 1 | a Lai, Meng-Chuan4 aut |
700 | 1 | a D'ardhuy, Xavier Liogier4 aut |
700 | 1 | a Lombardo, Michael V4 aut |
700 | 1 | a Lythgoe, David J4 aut |
700 | 1 | a Mandl, René4 aut |
700 | 1 | a Mason, Luke4 aut |
700 | 1 | a Meyer-Lindenberg, Andreas4 aut |
700 | 1 | a Moessnang, Carolin4 aut |
700 | 1 | a Mueller, Nico4 aut |
700 | 1 | a O'Dwyer, Laurence4 aut |
700 | 1 | a Oldehinkel, Marianne4 aut |
700 | 1 | a Oranje, Bob4 aut |
700 | 1 | a Pandina, Gahan4 aut |
700 | 1 | a Persico, Antonio M4 aut |
700 | 1 | a Ruggeri, Barbara4 aut |
700 | 1 | a Ruigrok, Amber N V4 aut |
700 | 1 | a Sabet, Jessica4 aut |
700 | 1 | a Sacco, Roberto4 aut |
700 | 1 | a Cáceres, Antonia San Jóse4 aut |
700 | 1 | a Simonoff, Emily4 aut |
700 | 1 | a Toro, Roberto4 aut |
700 | 1 | a Tost, Heike4 aut |
700 | 1 | a Waldman, Jack4 aut |
700 | 1 | a Williams, Steve C R4 aut |
700 | 1 | a Zwiers, Marcel P4 aut |
700 | 1 | a Spooren, Will4 aut |
700 | 1 | a Murphy, Declan G M4 aut |
700 | 1 | a Buitelaar, Jan K4 aut |
710 | 2 | a Karolinska Institutetb Barn- och ungdomspsykiatri4 org |
773 | 0 | t Molecular Autismd : Springer Science and Business Media LLCg 8q 8x 2040-2392 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1115619/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1186/s13229-017-0145-9 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325672 |
856 | 4 8 | u https://doi.org/10.1186/s13229-017-0145-9 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:136090653 |
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