Multifunctional Gadolinium-Doped Mesoporous TiO2 Nanobeads: Photoluminescence, Enhanced Spin Relaxation, and Reactive Oxygen Species Photogeneration, Beneficial for Cancer Diagnosis and Treatment

Imani, RoghayehUppsala universitet,Strukturkemi,Leibniz Univ Hannover, Inst Tech Chem, Callinstr 3, D-30167 Hannover, Germany.;Univ Ljubljana, Fac Elect Engn, Biophys Lab, SI-1000 Ljubljana, Slovenia. (author)

Multifunctional Gadolinium-Doped Mesoporous TiO2 Nanobeads : Photoluminescence, Enhanced Spin Relaxation, and Reactive Oxygen Species Photogeneration, Beneficial for Cancer Diagnosis and Treatment

Materials with controllable multifunctional abilities for optical imaging (OI) and magnetic resonant imaging (MRI) that also can be used in photodynamic therapy are very interesting for future applications. Mesoporous TiO2 sub-micrometer particles are doped with gadolinium to improve photoluminescence functionality and spin relaxation for MRI, with the added benefit of enhanced generation of reactive oxygen species (ROS). The Gd-doped TiO2 exhibits red emission at 637 nm that is beneficial for OI and significantly improves MRI relaxation times, with a beneficial decrease in spin-lattice and spin-spin relaxation times. Density functional theory calculations show that Gd3+ ions introduce impurity energy levels inside the bandgap of anatase TiO2, and also create dipoles that are beneficial for charge separation and decreased electron-hole recombination in the doped lattice. The Gd-doped TiO2 nanobeads (NBs) show enhanced ability for ROS monitored via center dot OH radical photogeneration, in comparison with undoped TiO2 nanobeads and TiO2 P25, for Gd-doping up to 10%. Cellular internalization and biocompatibility of TiO2@xGd NBs are tested in vitro on MG-63 human osteosarcoma cells, showing full biocompatibility. After photoactivation of the particles, anticancer trace by means of ROS photogeneration is observed just after 3 min irradiation.

Dillert, RalfLeibniz Univ Hannover, Inst Tech Chem, Callinstr 3, D-30167 Hannover, Germany.;Leibniz Univ Hannover, Lab Nano & Quantum Engn, Schneiderberg 39, D-30167 Hannover, Germany. (author)
Bahnemann, Detlef W.Leibniz Univ Hannover, Inst Tech Chem, Callinstr 3, D-30167 Hannover, Germany.;St Petersburg State Univ, Lab Photoact Nanocomposite Mat, St Petersburg 198504, Russia. (author)
Pazoki, MeysamUppsala universitet,Strukturkemi,Fasta tillståndets fysik(Swepub:uu)meypa799 (author)
Apih, TomazJozef Stefan Inst, Jamova 39, SI-1000 Ljubljana, Slovenia. (author)
Kononenko, VenoUniv Ljubljana, Dept Biol, Biotech Fac, Vecna Pot 111, SI-1000 Ljubljana, Slovenia. (author)
Repar, NezaUniv Ljubljana, Dept Biol, Biotech Fac, Vecna Pot 111, SI-1000 Ljubljana, Slovenia. (author)
Kralj-Iglic, VeronikaUniv Ljubljana, Fac Hlth Sci, Biophys Lab, SI-1000 Ljubljana, Slovenia. (author)
Boschloo, GerritUppsala universitet,Fysikalisk kemi(Swepub:uu)gerrbosc (author)
Drobne, DamjanaUniv Ljubljana, Dept Biol, Biotech Fac, Vecna Pot 111, SI-1000 Ljubljana, Slovenia. (author)
Edvinsson, Tomas,1970-Uppsala universitet,Fasta tillståndets fysik(Swepub:uu)tomaedvi (author)
Iglic, AlesUniv Ljubljana, Fac Elect Engn, Biophys Lab, SI-1000 Ljubljana, Slovenia. (author)
Uppsala universitetStrukturkemi (creator_code:org_t)

By the author/editor: Imani, Roghayeh; Dillert, Ralf; Bahnemann, Detle ...; Pazoki, Meysam; Apih, Tomaz; Kononenko, Veno; show more...; Repar, Neza; Kralj-Iglic, Ver ...; Boschloo, Gerrit; Drobne, Damjana; Edvinsson, Tomas ...; Iglic, Ales; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Physical Science ...; and Condensed Matter ...

NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Materials Chemis ...

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