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  • El-Jawahri, AreejMassachusetts Gen Hosp, Boston, MA 02114 USA. (author)

Impact of pre-transplant depression on outcomes of allogeneic and autologous hematopoietic stem cell transplantation

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-01-19
  • Wiley,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-325705
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325705URI
  • https://doi.org/10.1002/cncr.30546DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135795987URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: To evaluate the impact of depression before autologous and allogeneic hematopoietic cell transplantation (HCT) on clinical outcomes post-transplantation.METHODS: We analyzed data from the Center for International Blood and Marrow Transplant Research to compare outcomes after autologous (n=3786) or allogeneic (n=7433) HCT for adult patients with hematologic malignancies with an existing diagnosis of pre-HCT depression requiring treatment versus those without pre-HCT depression. Using Cox regression models, we compared overall survival (OS) between patients with or without depression. We compared the number of days alive and out of the hospital in the first 100 days post-HCT using Poisson models. We also compared the incidence of grade 2-4 acute and chronic graft-versus-host disease (GVHD) in allogeneic HCT.RESULTS: The study included 1116 (15%) patients with pre-transplant depression and 6317 (85%) without depression who underwent allogeneic HCT between 2008 and 2012. Pre-transplant depression was associated with lower OS (hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.04-1.23; P=0.004) and a higher incidence of grade 2-4 acute GVHD (HR, 1.25; 95% CI, 1.14-1.37; P<0.0001), but similar incidence of chronic GVHD. Pre-transplant depression was associated with fewer days-alive-and-out-of-the hospital (means ratio [MR]=0.97; 95% CI, 0.95-0.99; P=0.004). There were 512 (13.5%) patients with Pre-transplant depression and 3274 (86.5%) without depression who underwent autologous HCT. Pre-transplant depression in autologous HCT was not associated with OS (HR, 1.15; 95% CI, 0.98-1.34; P=0.096) but was associated with fewer days alive and out of the hospital (MR, 0.98; 95% CI, 0.97-0.99; P=0.002).CONCLUSION: Pre-transplant depression was associated with lower OS and higher risk of acute GVHD among allogeneic HCT recipients and fewer days alive and out of the hospital during the first 100 days after autologous and allogeneic HCT. Patients with pre-transplant depression represent a population that is at risk for post-transplant complications.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Chen, Yi-BinMassachusetts Gen Hosp, Boston, MA 02114 USA. (author)
  • Brazauskas, RutaMed Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Milwaukee, WI 53226 USA. (author)
  • He, NayaMed Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
  • Lee, Stephanie J.Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA. (author)
  • Knight, Jennifer M.Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
  • Majhail, NavneetCleveland Clin, Cleveland, OH 44106 USA. (author)
  • Buchbinder, DavidChildrens Hosp Orange Cty, Orange, CA USA. (author)
  • Schears, Raquel M.Brandeis Univ, Waltham, MA USA. (author)
  • Wirk, Baldeep M.Seattle Canc Care Alliance, Seattle, WA USA. (author)
  • Wood, William A.Univ N Carolina, Chapel Hill, NC USA. (author)
  • Ahmed, IbrahimChildrens Mercy Hosp & Clin, Kansas City, MO USA. (author)
  • Aljurf, MahmoudKing Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia. (author)
  • Szer, JeffRoyal Melbourne Hosp, Parkville, Vic, Australia. (author)
  • Beattie, Sara M.Univ Ottawa, Ottawa, ON, Canada. (author)
  • Battiwalla, MinooNHLBI, Bldg 10, Bethesda, MD 20892 USA. (author)
  • Dandoy, ChristopherCincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. (author)
  • Diaz, Miguel-AngelHosp Infantil Univ Nino Jesus, Madrid, Spain. (author)
  • D'Souza, AnitaMed Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
  • Freytes, Cesar O.Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. (author)
  • Gajewski, JamesOregon Hlth & Sci Univ, Portland, OR 97201 USA. (author)
  • Gergis, UsamaNew York Presbyterian Hosp, New York, NY USA. (author)
  • Hashmi, Shahrukh K.Brandeis Univ, Waltham, MA USA. (author)
  • Jakubowski, AnnMem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA. (author)
  • Kamble, Rammurti T.Baylor Coll Med, Houston, TX 77030 USA. (author)
  • Kindwall-Keller, TamilaUniv Virginia Hlth Syst, Charlottesville, VA USA. (author)
  • Lazarus, Hilard M.Seidman Canc Ctr, Cleveland, OH USA. (author)
  • Malone, Adriana K.Tisch Canc Inst, New York, NY USA. (author)
  • Marks, David I.Univ Hosp Bristol NHS Trust, Bristol, Avon, England. (author)
  • Meehan, KennethDartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA. (author)
  • Savani, Bipin N.Vanderbilt Univ, Med Ctr, Nashville, TN USA. (author)
  • Olsson, Richard F.Karolinska Institutet,Uppsala universitet,Hematologi,Karolinska Inst, Stockholm, Sweden.(Swepub:uu)riols677 (author)
  • Rizzieri, DavidDuke Univ, Durham, NC USA. (author)
  • Steinberg, AmirMt Sinai Hosp, New York, NY 10029 USA. (author)
  • Speckhart, DawnNorthside Hosp, Atlanta, GA USA. (author)
  • Szwajcer, DavidUniv Manitoba, Winnipeg, MB, Canada. (author)
  • Schoemans, HeleneUniv Hosp Leuven, Leuven, Belgium. (author)
  • Seo, SachikoEast Hosp, Kashiwa, Chiba, Japan. (author)
  • Ustun, CelalettinUniv Minnesota, Med Ctr, Minneapolis, MN 55455 USA. (author)
  • Atsuta, YoshikoJapanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan.;Nagoya Univ, Grad Sch Med, Nagoya, Aichi, Japan. (author)
  • Dalal, JigneshChildrens Mercy Hosp & Clin, Kansas City, MO USA. (author)
  • Sales-Bonfim, CarmemUniv Fed Parana, Hosp Clin, Curitiba, Parana, Brazil. (author)
  • Khera, NanditaMayo Clin, Phoenix, AZ USA. (author)
  • Hahn, TheresaRoswell Pk Canc Inst, Buffalo, NY 14263 USA. (author)
  • Saber, WaelMed Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (author)
  • Massachusetts Gen Hosp, Boston, MA 02114 USA.Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Milwaukee, WI 53226 USA. (creator_code:org_t)

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