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  • Landray, Martin J.Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England. (author)

Improving public health by improving clinical trial guidelines and their application

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-03-08
  • OXFORD UNIV PRESS,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-327135
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327135URI
  • https://doi.org/10.1093/eurheartj/ehx086DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Evidence generated from randomized controlled trials forms the foundation of cardiovascular therapeutics and has led to the adoption of numerous drugs and devices that prolong survival and reduce morbidity, as well as the avoidance of interventions that have been shown to be ineffective or even unsafe. Many aspects of cardiovascular research have evolved considerably since the first randomized trials in cardiology were conducted. In order to be large enough to provide reliable evidence about effects on major outcomes, cardiovascular trials may now involve thousands of patients recruited from hundreds of clinical sites in many different countries. Costly infrastructure has developed to meet the increasingly complex organizational and operational requirements of these clinical trials. Concerns have been raised that this approach is unsustainable, inhibiting the reliable evaluation of new and existing treatments, to the detriment of patient care. These issues were considered by patients, regulators, funders, and trialists at a meeting of the European Society of Cardiology Cardiovascular Roundtable in October 2015. This paper summarizes the key insights and discussions from the workshop, highlights subsequent progress, and identifies next steps to produce meaningful change in the conduct of cardiovascular clinical research.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bax, Jeroen J.Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands. (author)
  • Alliot, LaurenceServier, Paris, France. (author)
  • Buyse, MarcIDDI, Louvain La Neuve, Belgium.;CluePoints, Louvain La Neuve, Belgium.;Univ Hasselt, Hasselt, Belgium. (author)
  • Cohen, AdamCtr Human Drug Res, Leiden, Netherlands. (author)
  • Collins, RoryUniv Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England. (author)
  • Hindricks, GerhardUniv Leipzig, Heart Ctr, Dept Elect, Leipzig, Germany. (author)
  • James, Stefan K,1964-Uppsala universitet,Kardiologi(Swepub:uu)stjam367 (author)
  • Lane, SileSense Sci, London, England. (author)
  • Maggioni, Aldo P.ANMCO Res Ctr, Florence, Italy. (author)
  • Meeker-O'Connell, AnnJohnson & Johnson, New Brunswick, NJ USA. (author)
  • Olsson, GunnarEuropean Soc Cardiol, Jonkoping, Sweden. (author)
  • Pocock, Stuart J.London Sch Hyg & Trop Med, Dept Med Stat, London, England. (author)
  • Rawlins, MichaelMed & Healthcare Prod Regulatory Agcy, London, England. (author)
  • Sellors, JonathanHoward Kennedy, LLP, London, England. (author)
  • Shinagawa, KaoriPharmaceut & Med Devices Agcy, Tokyo, Japan. (author)
  • Sipido, Karin R.Univ Leuven, KU Leuven, Dept Cardiovasc Sci Expt Cardiol, Leuven, Belgium. (author)
  • Smeeth, LiamLondon Sch Hyg & Trop Med, Dept Med Stat, London, England. (author)
  • Stephens, RichardNatl Inst Canc Res, Consumer Lead, London, England. (author)
  • Stewart, Murray W.GlaxoSmithKline, Philadelphia, PA USA. (author)
  • Stough, Wendy GattisCampbell Univ, Coll Pharm & Hlth Sci, Buies Creek, NC 27506 USA. (author)
  • Sweeney, FergusEuropean Med Agcy, London, England. (author)
  • Van de Werf, FransUniv Hosp, Dept Cardiovasc Sci, Leuven, Belgium. (author)
  • Woods, KerrieNatl Inst Hlth Res, Natl Hlth Serv, London, England. (author)
  • Casadei, BarbaraUniv Oxford, John Radcliffe Hosp, Div Cardiovasc Med, Radcliffe Dept Med, Level 6,West Wing, Oxford OX3 9DU, England. (author)
  • Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England.Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands. (creator_code:org_t)

Related titles

  • In:European Heart Journal: OXFORD UNIV PRESS38:21, s. 1632-1637B0195-668X1522-9645

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