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The Lifespan and Tu...
The Lifespan and Turnover of Microglia in the Human Brain
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Reu, Pedro (author)
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Khosravi, Azadeh (author)
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Bernard, Samuel (author)
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- Mold, Jeff E. (author)
- Karolinska Institutet
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- Salehpour, Mehran, 1960- (author)
- Uppsala universitet,Tillämpad kärnfysik,Ion physics
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- Alkass, Kanar (author)
- Karolinska Institutet
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Perl, Shira (author)
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Tisdale, John (author)
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- Possnert, Göran, 1951- (author)
- Uppsala universitet,Tillämpad kärnfysik
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- Druid, Henrik (author)
- Karolinska Institutet
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- Frisen, Jonas (author)
- Karolinska Institutet
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(creator_code:org_t)
- Cambridge, MA 02139, USA : Elsevier BV, 2017
- 2017
- English.
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In: Cell Reports. - Cambridge, MA 02139, USA : Elsevier BV. - 2211-1247. ; 20:4, s. 779-784
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other hematopoietic lineages, renew slowly at a median rate of 28% per year, and some microglia last for more than two decades. Furthermore, we find no evidence for the existence of a substantial population of quiescent long-lived cells, meaning that the microglia population in the human brain is sustained by continuous slow turnover throughout adult life.
Subject headings
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- Cell turnover
- regeneration
- microglia
- human brain
- Ion Physics
- Jonfysik
- Biology with specialization in Molecular Cell Biology
- Biologi med inriktning mot molekylär cellbiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Reu, Pedro
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Khosravi, Azadeh
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Bernard, Samuel
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Mold, Jeff E.
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Salehpour, Mehra ...
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Alkass, Kanar
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show more...
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Perl, Shira
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Tisdale, John
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Possnert, Göran, ...
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Druid, Henrik
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Frisen, Jonas
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Cell Reports
- By the university
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Uppsala University
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Karolinska Institutet