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Design and rational...
Design and rationale for the Influenza vaccination After Myocardial Infarction (IAMI) trial. A registry-based randomized clinical trial
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- Fröbert, Ole, 1964- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Fac Hlth, Dept Cardiol, S-70185 Orebro, Sweden.
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- Götberg, Matthias (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Angerås, Oskar (author)
- Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.,Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Jonasson, Lena (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping University Hospital
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- Erlinge, David (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Engstrøm, Thomas (author)
- Univ Copenhagen, Dept Cardiol, Rigshosp, Copenhagen, Denmark.,Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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- Persson, Jonas (author)
- Karolinska Institutet,Karolinska Institute,Danderyd Hospital
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- Jensen, Svend E. (author)
- Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.,Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Omerovic, Elmir (author)
- Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.,Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- James, Stefan K, 1964- (author)
- Uppsala universitet,Kardiologi,Department of Cardiology, University Hospital Uppsala, Uppsala, Sweden
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- Lagerqvist, Bo, 1952- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Cardiology, University Hospital Uppsala, Uppsala, Sweden
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- Nilsson, Johan (author)
- Umeå universitet,Kardiologi,Heart Centre,Umea Univ, Dept Publ Hlth & Clin Med, Heart Ctr, Cardiol, Umea, Sweden.,Umeå University, Sweden
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- Kåregren, Amra (author)
- Vesteras Cty Hosp, Dept Cardiol, Vasteras, Sweden.,Department of Cardiology, Västerås County Hospital, Västerås, Sweden,Västmanland Hospital
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- Moer, Rasmus (author)
- The Feiring Clinic, Feiring, Norway
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- Cao, Yang, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Unit of Biostatistics, Institute of Evironmental Medicine, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics,Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden.;Karolinska Inst, Inst Evironmentol Med, Unit Biostat, Stockholm, Sweden.,Örebro University, Sweden; Karolinska Institute, Sweden
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- Agus, David B. (author)
- Univ Southern Calif, Lawrence J Ellison Inst Transformat Med, Los Angeles, CA 90089 USA.,Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, United States,University of Southern Calif, CA 90089 USA
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- Erglis, Andrejs (author)
- Pauls Stradins Clin Univ Hosp, Latvian Ctr Cardiol, Riga, Latvia.,Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia,Pauls Stradins Clin University Hospital, Latvia,Riga Eastern Clinical University Hospital
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- Jensen, Lisette O. (author)
- Odense Univ Hosp, Dept Cardiol, Odense, Denmark.,Department of Cardiology, Odense University Hospital, Odense, Denmark
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- Jakobsen, Lars (author)
- Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark.,Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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- Christiansen, Evald H. (author)
- Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark.,Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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- Pernow, John (author)
- Karolinska Institutet
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(creator_code:org_t)
- MOSBY-ELSEVIER, 2017
- 2017
- English.
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In: American Heart Journal. - : MOSBY-ELSEVIER. - 0002-8703 .- 1097-6744. ; 189, s. 94-102
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Abstract
Subject headings
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- Background: Registry studies and case-control studies have demonstrated that the risk of acute myocardial infarction (AMI) is increased following influenza infection. Small randomized trials, underpowered for clinical end points, indicate that future cardiovascular events can be reduced following influenza vaccination in patients with established cardiovascular disease. Influenza vaccination is recommended by international guidelines for patients with cardiovascular disease, but uptake is varying and vaccination is rarely prioritized during hospitalization for AMI.Methods/design: The Influenza vaccination After Myocardial Infarction (IAMI) trial is a double-blind, multicenter, prospective, registry-based, randomized, placebo-controlled, clinical trial. A total of 4,400 patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI undergoing coronary angiography will randomly be assigned either to in-hospital influenza vaccination or to placebo. Baseline information is collected from national heart disease registries, and follow-up will be performed using both registries and a structured telephone interview. The primary end point is a composite of time to all cause death, a new AMI, or stent thrombosis at 1 year.Implications: The IAMI trial is the largest randomized trial to date to evaluate the effect of in-hospital influenza vaccination on death and cardiovascular outcomes in patients with STEMI or non-STEMI. The trial is expected to provide highly relevant clinical data on the efficacy of influenza vaccine as secondary prevention after AMI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fröbert, Ole, 19 ...
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Götberg, Matthia ...
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Angerås, Oskar
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Jonasson, Lena
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Erlinge, David
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Engstrøm, Thomas
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show more...
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Persson, Jonas
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Jensen, Svend E.
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Omerovic, Elmir
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James, Stefan K, ...
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Lagerqvist, Bo, ...
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Nilsson, Johan
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Kåregren, Amra
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Moer, Rasmus
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Cao, Yang, 1972-
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Agus, David B.
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Erglis, Andrejs
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Jensen, Lisette ...
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Jakobsen, Lars
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Christiansen, Ev ...
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Pernow, John
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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American Heart J ...
- By the university
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Uppsala University
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Örebro University
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Umeå University
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Linköping University
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Lund University
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Karolinska Institutet