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  • Fröbert, Ole,1964-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Fac Hlth, Dept Cardiol, S-70185 Orebro, Sweden. (author)

Design and rationale for the Influenza vaccination After Myocardial Infarction (IAMI) trial. A registry-based randomized clinical trial

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • MOSBY-ELSEVIER,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-328969
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328969URI
  • https://doi.org/10.1016/j.ahj.2017.04.003DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-58939URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137793URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-139393URI
  • https://lup.lub.lu.se/record/af1382ee-ab70-4f88-9ed5-dd9beb23f968URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136108102URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Registry studies and case-control studies have demonstrated that the risk of acute myocardial infarction (AMI) is increased following influenza infection. Small randomized trials, underpowered for clinical end points, indicate that future cardiovascular events can be reduced following influenza vaccination in patients with established cardiovascular disease. Influenza vaccination is recommended by international guidelines for patients with cardiovascular disease, but uptake is varying and vaccination is rarely prioritized during hospitalization for AMI.Methods/design: The Influenza vaccination After Myocardial Infarction (IAMI) trial is a double-blind, multicenter, prospective, registry-based, randomized, placebo-controlled, clinical trial. A total of 4,400 patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI undergoing coronary angiography will randomly be assigned either to in-hospital influenza vaccination or to placebo. Baseline information is collected from national heart disease registries, and follow-up will be performed using both registries and a structured telephone interview. The primary end point is a composite of time to all cause death, a new AMI, or stent thrombosis at 1 year.Implications: The IAMI trial is the largest randomized trial to date to evaluate the effect of in-hospital influenza vaccination on death and cardiovascular outcomes in patients with STEMI or non-STEMI. The trial is expected to provide highly relevant clinical data on the efficacy of influenza vaccine as secondary prevention after AMI.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Götberg, MatthiasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-mgo (author)
  • Angerås, OskarSahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.,Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden (author)
  • Jonasson, LenaLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping University Hospital(Swepub:liu)lenjo59 (author)
  • Erlinge, DavidLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-der (author)
  • Engstrøm, ThomasUniv Copenhagen, Dept Cardiol, Rigshosp, Copenhagen, Denmark.,Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark(Swepub:lu)th4331en (author)
  • Persson, JonasKarolinska Institutet,Karolinska Institute,Danderyd Hospital(Swepub:lu)ftf-jpe (author)
  • Jensen, Svend E.Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.,Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark (author)
  • Omerovic, ElmirSahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.,Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden (author)
  • James, Stefan K,1964-Uppsala universitet,Kardiologi,Department of Cardiology, University Hospital Uppsala, Uppsala, Sweden(Swepub:uu)stjam367 (author)
  • Lagerqvist, Bo,1952-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Cardiology, University Hospital Uppsala, Uppsala, Sweden(Swepub:uu)bolager (author)
  • Nilsson, JohanUmeå universitet,Kardiologi,Heart Centre,Umea Univ, Dept Publ Hlth & Clin Med, Heart Ctr, Cardiol, Umea, Sweden.,Umeå University, Sweden(Swepub:umu)joni0050 (author)
  • Kåregren, AmraVesteras Cty Hosp, Dept Cardiol, Vasteras, Sweden.,Department of Cardiology, Västerås County Hospital, Västerås, Sweden,Västmanland Hospital (author)
  • Moer, RasmusThe Feiring Clinic, Feiring, Norway (author)
  • Cao, Yang,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Unit of Biostatistics, Institute of Evironmental Medicine, Karolinska Institutet, Stockholm, Sweden,Clinical Epidemiology and Biostatistics,Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden.;Karolinska Inst, Inst Evironmentol Med, Unit Biostat, Stockholm, Sweden.,Örebro University, Sweden; Karolinska Institute, Sweden(Swepub:oru)yco (author)
  • Agus, David B.Univ Southern Calif, Lawrence J Ellison Inst Transformat Med, Los Angeles, CA 90089 USA.,Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, United States,University of Southern Calif, CA 90089 USA (author)
  • Erglis, AndrejsPauls Stradins Clin Univ Hosp, Latvian Ctr Cardiol, Riga, Latvia.,Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia,Pauls Stradins Clin University Hospital, Latvia,Riga Eastern Clinical University Hospital (author)
  • Jensen, Lisette O.Odense Univ Hosp, Dept Cardiol, Odense, Denmark.,Department of Cardiology, Odense University Hospital, Odense, Denmark (author)
  • Jakobsen, LarsAarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark.,Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (author)
  • Christiansen, Evald H.Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark.,Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (author)
  • Pernow, JohnKarolinska Institutet (author)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:American Heart Journal: MOSBY-ELSEVIER189, s. 94-1020002-87031097-6744

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