SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-328974"
 

Search: onr:"swepub:oai:DiVA.org:uu-328974" > Numerous Ontogeneti...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Numerous Ontogenetic Roads to Mantle Cell Lymphoma : Immunogenetic and Immunohistochemical Evidence

Pouliou, Evi (author)
Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece.;Univ Athens, Sch Med, Dept Pathol, Athens, Greece.
Xochelli, Aliki (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Ctr Res & Technol Hellas CERTH, Inst Appl Biosci, Thessaloniki, Greece
Kanellis, George (author)
Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece.
show more...
Stalika, Evangelia (author)
Ctr Res & Technol Hellas CERTH, Inst Appl Biosci, Thessaloniki, Greece.
Sutton, Lesley-Ann (author)
Karolinska Institutet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
Navarro, Alba (author)
Hosp Clin Barcelona, Dept Pathol, Barcelona, Spain.;Univ Barcelona, Inst Biomed Res August Pi i Sunyer, Barcelona, Spain.
Agathangelidis, Andreas (author)
Ist Sci San Raffaele, IRCCS, Div Mol Oncol, Milan, Italy.;Ist Sci San Raffaele, IRCCS, Dept Oncohematol, Milan, Italy.;Univ Vita Salutte San Raffaele, Milan, Italy.
Dimosthenous, Kypros (author)
Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece.
Anagnostopoulos, Achilles (author)
G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, Hematopoiet Cell Transplantat Unit, Thessaloniki, Greece.
Patsouris, Efstratios (author)
Univ Athens, Sch Med, Dept Pathol, Athens, Greece.
Korkolopoulou, Penelope (author)
Univ Athens, Sch Med, Dept Pathol, Athens, Greece.
Sundström, Christer (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi,Rose-Marie Amini
Ghia, Paolo (author)
Ist Sci San Raffaele, IRCCS, Div Mol Oncol, Milan, Italy.;Ist Sci San Raffaele, IRCCS, Dept Oncohematol, Milan, Italy.;Univ Vita Salutte San Raffaele, Milan, Italy.
Ponzoni, Maurilio (author)
Ist Sci San Raffaele, Milan, Italy.
Sander, Birgitta (author)
Karolinska Institutet
Campo, Elias (author)
Hosp Clin Barcelona, Dept Pathol, Barcelona, Spain.;Univ Barcelona, Inst Biomed Res August Pi i Sunyer, Barcelona, Spain.
Rosenquist, Richard (author)
Karolinska Institutet
Hadzidimitriou, Anastasia (author)
Ctr Res & Technol Hellas CERTH, Inst Appl Biosci, Thessaloniki, Greece.
Stamatopoulos, Kostas (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Ctr Res & Technol Hellas CERTH, Inst Appl Biosci, Thessaloniki, Greece.;G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, Hematopoiet Cell Transplantat Unit, Thessaloniki, Greece.
Papadaki, Theodora (author)
Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece.
show less...
Evangelismos Med Ctr, Hematopathol Dept, Athens, Greece;Univ Athens, Sch Med, Dept Pathol, Athens, Greece. Science for Life Laboratory, SciLifeLab (creator_code:org_t)
ELSEVIER SCIENCE INC, 2017
2017
English.
In: American Journal of Pathology. - : ELSEVIER SCIENCE INC. - 0002-9440 .- 1525-2191. ; 187:7, s. 1454-1458
Related links:
http://ajp.amjpathol...
show more...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • To obtain insight into the ontogeny of mantle cell lymphoma (MCL), we assessed 206 patients from a morphological, immunohistochemical, and immunogenetic perspective. Our series included nodal (n = 151), extranodal. (n = 28), and primary splenic (n = 27) MCL cases. Skewing of the immunoglobulin heavy variable (IGHV) gene repertoire was noted, with only four IGHV genes accounting for 46% of cases and approximately 70% of cases (107/154) bearing an imprint of somatic hypermutation (SHM) ranging from minimalto pronounced. Interestingly, a distinctive immunophenotypic and immunogenetic profile was identified for primary splenic MCL, which was enriched for DBA.44-positive cases (P < 0.001) and used the IGHV1-8 gene more frequently (P = 0.02) compared to nodal or extranodal cases, alluding to distinct immunopathogenetic and antigen selection processes. Expression of CD27 (considered a marker of activated B cells) was generally dissociated from SHM and was more prevalent in cases with no or minimal/borderline SHM. These findings support the idea that antigen drive is relevant for most MCL cases, although the specific antigens and the precise location of affinity maturation remain to be elucidated. Moreover, they raise the intriguing hypothesis of multiple cellular origins for MCL.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

Keyword

Pathology
Patologi

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view