Lifestyle and Risk of Screening-Detected Abdominal Aortic Aneurysm in Men

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Stackelberg, OttoKarolinska Institutet,Uppsala universitet,Kärlkirurgi,Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Box 210, SE-17177 Stockholm, Sweden.;Soder Sjukhuset, Dept Surg, Stockholm, Sweden. (author)

Lifestyle and Risk of Screening-Detected Abdominal Aortic Aneurysm in Men

Article/chapterEnglish2017

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2017
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LIBRIS-ID:oai:DiVA.org:uu-329114
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329114URI
https://doi.org/10.1161/JAHA.116.004725DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:136129893URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Background-Modifiable lifestyle-related factors associated with risk of abdominal aortic aneurysm (AAA) are rarely investigated with a prospective design. We aimed to study possible associations among such factors and comorbidities with mean abdominal aortic diameter (AAD) and with risk of AAA among men screened for the disease. Methods and Results-Self-reported lifestyle-related exposures were assessed at baseline (January 1, 1998) among 14 249 men from the population-based Cohort of Swedish Men, screened for AAA between 65 and 75 years of age (mean 13 years after baseline). Multivariable prediction of mean AAD was estimated with linear regression, and hazard ratios (HRs) of AAA (AAD >= 30 mm) with Cox proportional hazard regression. The AAA prevalence was 1.2% (n=168). Smoking, body mass index, and cardiovascular disease were associated with a larger mean AAD, whereas consumption of alcohol and diabetes mellitus were associated with a smaller mean AAD. The HR of AAA was increased among participants who were current smokers with >= 25 pack-years smoked compared with never smokers (HR 15.59, 95% CI 8.96-27.15), those with a body mass index >= 25 versus <25 ( HR 1.89, 95% CI, 1.22-2.93), and those with cardiovascular disease (HR 1.77, 95% CI, 1.13-2.77), and hypercholesterolemia (HR 1.59, 95% CI 1.08-2.34). Walking or bicycling for >40 minutes/day (versus almost never) was associated with lower AAA hazard (HR 0.59, 95% CI 0.36-0.97) compared with almost never walking or bicycling. Conclusions-This prospective study confirms that modifiable lifestyle-related factors are associated with AAD and with AAA disease.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
abdominal aortic aneurysm
cohort study
epidemiology
lifestyle
risk factor

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Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Kärlkirurgi,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Box 210, SE-17177 Stockholm, Sweden.(Swepub:uu)alwol516 (author)
Eliasson, KenOrebro Univ Hosp, Dept Cardiovasc Surg, Sect Vasc Surg, Orebro, Sweden. (author)
Hellberg, AndersUppsala universitet,Kärlkirurgi,Centrum för klinisk forskning, Västerås (author)
Bersztel, AdamUppsala universitet,Centrum för klinisk forskning, Västerås,Kärlkirurgi (author)
Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Box 210, SE-17177 Stockholm, Sweden.(Swepub:uu)susla720 (author)
Orsini, NicolaKarolinska Institutet (author)
Wanhainen, AndersUppsala universitet,Kärlkirurgi(Swepub:uu)anwan103 (author)
Björck, MartinUppsala universitet,Kärlkirurgi(Swepub:uu)mabjo425 (author)
Uppsala universitetKärlkirurgi (creator_code:org_t)

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In:Journal of the American Heart Association6:52047-9980

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

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