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  • Mair, JohannesMed Univ Innsbruck, Dept Internal Med Cardiol & Angiol 3, Innsbruck, Austria. (author)

Will sacubitril-valsartan diminish the clinical utility of B-type natriuretic peptide testing in acute cardiac care?

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-01-12
  • Oxford University Press (OUP),2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-329722
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329722URI
  • https://doi.org/10.1177/2048872615626355DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Since the approval of sacubitril-valsartan for the treatment of chronic heart failure with reduced ejection fraction, a commonly raised suspicion is that a wider clinical use of this new drug may diminish the clinical utility of B-type natriuretic peptide testing as sacubitril may interfere with B-type natriuretic peptide clearance. In this education paper we critically assess this hypothesis based on the pathophysiology of the natriuretic peptide system and the limited published data on the effects of neprilysin inhibition on natriuretic peptide plasma concentrations in humans. As the main clinical application of B-type natriuretic peptide testing in acute cardiac care is and will be the rapid rule-out of suspected acute heart failure there is no significant impairment to be expected for B-type natriuretic peptide testing in the acute setting. However, monitoring of chronic heart failure patients on sacubitril-valsartan treatment with B-type natriuretic peptide testing may be impaired. In contrast to N-terminal-proBNP, the current concept that the lower the B-type natriuretic peptide result in chronic heart failure patients, the better the prognosis during treatment monitoring, may no longer be true.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Lindahl, Bertil,1957-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227 (author)
  • Giannitsis, EvangelosHeidelberg Univ, Med Klin 3, Heidelberg, Germany. (author)
  • Huber, KurtWilhelminen Hosp, Dept Med Cardiol & Intens Care Med, Vienna, Austria. (author)
  • Thygesen, KristianAarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark. (author)
  • Plebani, MarioUniv Hosp Padova, Dept Lab Med, Padua, Italy. (author)
  • Moeckel, MartinCharite Univ Med Berlin, Div Emergency Med, Berlin, Germany.;Charite Univ Med Berlin, Dept Cardiol, Berlin, Germany. (author)
  • Mueller, ChristianUniv Hosp Basel, Dept Cardiol, Basel, Switzerland.;Univ Hosp Basel, Cardiovasc Res Inst Basel, Basel, Switzerland. (author)
  • Jaffe, Allan S. (author)
  • Med Univ Innsbruck, Dept Internal Med Cardiol & Angiol 3, Innsbruck, Austria.Kardiologi (creator_code:org_t)

Related titles

  • In:European Heart Journal: Oxford University Press (OUP)6:4, s. 321-3282048-87262048-8734

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