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Macrophage migratio...
Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1
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- Fex Svenningsen, Åsa (författare)
- University of Southern Denmark
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- Löring, Svenja (författare)
- University of Southern Denmark
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- Sørensen, Anna Lahn (författare)
- University of Southern Denmark
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- Huynh, Ha Uyen Buu (författare)
- University of Southern Denmark
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- Hjæresen, Simone (författare)
- University of Southern Denmark
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- Martin, Nellie (författare)
- University of Southern Denmark
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- Moeller, Jesper Bonnet (författare)
- University of Southern Denmark
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- Elkjær, Maria Louise (författare)
- University of Southern Denmark
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- Holmskov, Uffe (författare)
- University of Southern Denmark
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- Illes, Zsolt (författare)
- University of Southern Denmark
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- Andersson, Malin (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Research; Drug Safety and Toxicology
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- Nielsen, Solveig Beck (författare)
- University of Southern Denmark
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- Benedikz, Eirikur (författare)
- University of Southern Denmark
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(creator_code:org_t)
- 2017-07-19
- 2017
- Engelska.
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Ingår i: Cellular and Molecular Life Sciences (CMLS). - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 24, s. 4561-4572
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Macrophage migration inhibitory factor (MIF), a small conserved protein, is abundant in the immune- and central nervous system (CNS). MIF has several receptors and binding partners that can modulate its action on a cellular level. It is upregulated in neurodegenerative diseases and cancer although its function is far from clear. Here, we report the finding of a new binding partner to MIF, the serine protease HTRA1. This enzyme cleaves several growth factors, extracellular matrix molecules and is implicated in some of the same diseases as MIF. We show that the function of the binding between MIF and HTRA1 is to inhibit the proteolytic activity of HTRA1, modulating the availability of molecules that can change cell growth and differentiation. MIF is therefore the first endogenous inhibitor ever found for HTRA1. It was found that both molecules were present in astrocytes and that the functional binding has the ability to modulate astrocytic activities important in development and disease of the CNS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Nyckelord
- HTRA1
- MIF
- Protein interaction
- Yeast-2-hybrid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Fex Svenningsen, ...
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Löring, Svenja
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Sørensen, Anna L ...
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Huynh, Ha Uyen B ...
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Hjæresen, Simone
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Martin, Nellie
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visa fler...
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Moeller, Jesper ...
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Elkjær, Maria Lo ...
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Holmskov, Uffe
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Illes, Zsolt
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Andersson, Malin
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Nielsen, Solveig ...
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Benedikz, Eiriku ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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Cellular and Mol ...
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Uppsala universitet