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Self-assembled hyal...
Self-assembled hyaluronic acid nanoparticles for controlled release of agrochemicals and diosgenin
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- Quinones, Javier Pérez (author)
- Johannes Kepler Univ Linz, Inst Polymer Chem.
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- Bruggemann, Oliver (author)
- Johannes Kepler Univ Linz, Inst Polymer Chem.
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- Covas, Carlos Peniche (author)
- Univ Havana, Ctr Biomat.
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- Ossipov, Dmitri A. (author)
- Uppsala universitet,Polymerkemi
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Johannes Kepler Univ Linz, Inst Polymer Chem Univ Havana, Ctr Biomat. (creator_code:org_t)
- ELSEVIER SCI LTD, 2017
- 2017
- English.
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In: Carbohydrate Polymers. - : ELSEVIER SCI LTD. - 0144-8617 .- 1879-1344. ; 173, s. 157-169
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Commercial sodium hyaluronate (HA) and synthetic hydrazide-modified HA were functionalized with diosgenin and two agrochemicals (brassinosteroids DI31 and S7) with degree of substitution ranging from 5.6 to 13.1%. The HA-steroid conjugates were studied with FTIR, H-1 NMR and differential scanning calorimetry. Dynamic light scattering revealed self-assembly of the HA-steroid conjugates into stable negatively charged nanoparticles of around 159 nm-441 nm in water, which after drying appeared as 140 nm-370 nm spherically shaped nanoparticles according to transmission electron microscopy. These nanoparticles exhibited almost constant release rates of steroids for the first 8 h, demonstrating sustained steroids delivery for 72 h in acidic medium. The nanoparticles formed from HA-steroid conjugates were not cytotoxic to human microvascular endothelial cells (HMVEC), while the HA- brassinosteroid nanoparticles showed in vitro agrochemical activity that was superior to the activity observed for the parent brassinosteroids DI31 and S7 at 10(-5) to 10(-7) mg mL(-1).
Subject headings
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- Agrochemical
- Controlled release
- Hyaluronic scid
- Nanoparticles
- Steroids
Publication and Content Type
- ref (subject category)
- art (subject category)
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