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Chitinase-3-like pr...
Chitinase-3-like protein 1 (CH3L1) and Neurosecretory protein VGF (VGF) as two novel CSF biomarker candidates for improved diagnostics in Alzheimer’s disease
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- Emami Khoonsari, Payam (författare)
- Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
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- Shevchenko, Ganna (författare)
- Department of Chemistry-BMC, Analytical Chemistry, Uppsala University, Uppsala, Sweden.
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- Herman, Stephanie (författare)
- Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
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- Musunuri, Sravani (författare)
- Department of Chemistry-BMC, Analytical Chemistry, Uppsala University, Uppsala, Sweden.
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- Remnestål, Julia (författare)
- Affinity Proteomics, Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden.
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- Brundin, RoseMarie (författare)
- Department of Public Health/ Geriatrics, Uppsala University, Uppsala, Sweden.
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- Degerman Gunnarsson, Malin (författare)
- Department of Public Health/ Geriatrics, Uppsala University, Uppsala, Sweden.
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- Kilander, Lena (författare)
- Department of Public Health/ Geriatrics, Uppsala University, Uppsala, Sweden.
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- Zetterberg, Henrik (författare)
- Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.
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- Nilsson, Peter (författare)
- Affinity Proteomics, Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden.
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- Lannfelt, Lars (författare)
- Department of Public Health/ Geriatrics, Uppsala University, Uppsala, Sweden.
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- Ingelsson, Martin (författare)
- Department of Public Health/ Geriatrics, Uppsala University, Uppsala, Sweden.
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- Kultima, Kim (författare)
- Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
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Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden Department of Chemistry-BMC, Analytical Chemistry, Uppsala University, Uppsala, Sweden. (creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by amyloid-β (Aβ) plaque deposition and accumulation of intracellular neurofibrillary tangles. This pathology is mirrored in the cerebrospinal fluid (CSF), where decreased Aβ42 together with increased total (t-tau) and phospho-tau (p-tau) today is used as a diagnostic marker. Although these biomarkers have a fairly good sensitivity and specificity, additional biomarkers are needed to further improve the accuracy for early disease detection and to monitor disease development. In this study, we used mass spectrometry-based shotgun proteomics to investigate the CSF proteome of patients with AD and mild cognitive impairment (MCI) as well as of non-demented controls. By combining the diagnostic markers (Aβ42, total t-tau, and p-tau) with a selection of proteomics biomarkers, the accuracy of predicting MCI to AD conversion increased from 83% to 92% with a specificity of 1.0 and sensitivity of 0.86. Among these markers, the levels of protein chitinase-3-like protein 1 (CH3L1) were significantly higher in AD and MCI converters compared to controls. In addition to Aβ42, t-tau, and p-tau the protein CH3L1 contributed mostly to the prediction accuracy. We also found statistically significant lower CSF levels of the neurosecretory protein VGF (VGF) in AD compared to controls. Taken together, our findings suggest that incorporating new CSF biomarkers can further enhance early diagnosis of AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- cerebrospinal fluid
- biomarker
- diagnostics
- neurodegenerative disorder
- dementia
- Geriatrics
- Geriatrik
- Medical Science
- Medicinsk vetenskap
- Neurology
- Neurologi
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
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Emami Khoonsari, ...
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Shevchenko, Gann ...
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Herman, Stephani ...
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Musunuri, Sravan ...
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Remnestål, Julia
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Brundin, RoseMar ...
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visa fler...
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Degerman Gunnars ...
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Kilander, Lena
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Zetterberg, Henr ...
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Nilsson, Peter
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Lannfelt, Lars
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Ingelsson, Marti ...
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Kultima, Kim
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Geriatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Av lärosätet
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Uppsala universitet