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Patients with lymph...
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Ghaffarpour, NKarolinska Institutet
(author)
Patients with lymphatic malformations who receive the immunostimulant OK-432 experience excellent long-term outcomes
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-07-14
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Wiley,2015
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-332184
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-332184URI
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https://doi.org/10.1111/apa.13086DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:132293406URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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AIM: Sclerotherapy is the primary treatment for lymphatic malformations. The aim of this study was to evaluate the long-term outcome in patients with lymphatic malformations treated with the immunostimulant OK-432 as a sclerosant.METHODS: Between 1998 and 2013, we enrolled 131 of 138 eligible patients treated with OK-432 for lymphatic malformations in a retrospective study. The malformations were categorised according to the International Society for the Study of Vascular Anomalies. The outcome was assessed with a clinical examination and a questionnaire.RESULTS: The lymphatic malformations were localised to the head/neck (60%), the trunk (20%) and the extremities (6%) or involved with more than one region (14%). Patients with microcystic (10%), macrocystic (21%) and mixed lymphatic malformations (69%) underwent a median number of three, two and two injection treatments, respectively. The median age at the first injection was 3.4 years. Good or excellent clinical outcomes were seen in 70% of the patients. The number of injections, previous treatment and lesion localisation, but not time to follow-up and cyst size, predicted the clinical outcome.CONCLUSION: OK-432 treatment resulted in a successful outcome in 70% of patients with lymphatic malformations. The long-term outcome was comparable to the short-term outcome.
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Petrini, B
(author)
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Svensson, L A
(author)
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Boman, KKarolinska Institutet(Swepub:uu)kribo866
(author)
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Wester, TKarolinska Institutet
(author)
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Claesson, G
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Acta Paediatrica: Wiley104:11, s. 1169-730803-52531651-2227
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