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Epigenetic Regulati...
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Fedele, VitaUniv Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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AMER ASSOC CANCER RESEARCH,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-333714
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333714URI
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https://doi.org/10.1158/1541-7786.MCR-16-0494DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Glioblastoma (GBM) comprises distinct subtypes characterized by their molecular profile. Mesenchymal identity in GBM has been associated with a comparatively unfavorable prognosis, primarily due to inherent resistance of these tumors to current therapies. The identification of molecular determinants of mesenchymal transformation could potentially allow for the discovery of new therapeutic targets. Zinc Finger and BTB Domain Containing 18 (ZBTB18/ZNF238/RP58) is a zinc finger transcriptional repressor with a crucial role in brain development and neuronal differentiation. Here, ZBTB18 is primarily silenced in the mesenchymal subtype of GBM through aberrant promoter methylation. Loss of ZBTB18 contributes to the aggressive phenotype of glioblastoma through regulation of poor prognosis-associated signatures. Restitution of ZBTB18 expression reverses the phenotype and impairs tumor-forming ability. These results indicate that ZBTB18 functions as a tumor suppressor in GBM through the regulation of genes associated with phenotypically aggressive properties.
Added entries (persons, corporate bodies, meetings, titles ...)
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Dai, FangpingUniv Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
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Masilamani, Anie P.Univ Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
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Heiland, Dieter H.Univ Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
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Kling, EvaUniv Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
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Gätjens-Sanchez, Ana M.Univ Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
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Ferrarese, RobertoUniv Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
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Platania, LeonardoUniv Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
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Soroush, DoostkamUniv Freiburg, Neuroctr, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, Ctr Comprehens Canc, Freiburg, Germany.;Univ Freiburg, BIOSS Ctr Biol Signalling Studies, Freiburg, Germany.
(author)
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Kim, HyunsooJackson Lab Genom Med, Farmington, CT USA.
(author)
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Nelander, SvenUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)svene843
(author)
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Weyerbrock, AstridUniv Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
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Prinz, MarcoUniv Freiburg, Neuroctr, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, Ctr Comprehens Canc, Freiburg, Germany.;Univ Freiburg, BIOSS Ctr Biol Signalling Studies, Freiburg, Germany.
(author)
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Califano, AndreaColumbia Univ, Inst Canc Genet, New York, NY USA.;Columbia Univ, Dept Biomed Informat, New York, NY USA.;Columbia Univ, Dept Syst Biol, New York, NY USA.
(author)
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Iavarone, AntonioColumbia Univ, Inst Canc Genet, New York, NY USA.;Columbia Univ, Med Ctr, Dept Pathol, New York, NY USA.;Columbia Univ, Med Ctr, Dept Neurol, New York, NY USA.
(author)
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Bredel, MarkusUniv Alabama Birmingham, Sch Med, Ctr Comprehens Canc, Dept Radiat Oncol, Birmingham, AL USA.;Stanford Univ, Sch Med, Stanford Canc Inst, Dept Neurosurg, Stanford, CA 94305 USA.
(author)
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Carro, Maria S.Univ Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.
(author)
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Univ Freiburg, Med Ctr, Dept Neurosurg, Freiburg, Germany.;Univ Freiburg, Fac Med, Freiburg, Germany.Univ Freiburg, Neuroctr, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, Ctr Comprehens Canc, Freiburg, Germany.;Univ Freiburg, BIOSS Ctr Biol Signalling Studies, Freiburg, Germany.
(creator_code:org_t)
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In:Molecular Cancer Research: AMER ASSOC CANCER RESEARCH15:8, s. 998-10111541-77861557-3125
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Weyerbrock, Astr ...
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