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Effect of Surgery V...
Effect of Surgery Versus Observation : Skeletal 5-Year Outcomes in a Randomized Trial of Patients With Primary HPT (the SIPH Study)
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- Lundstam, Karolina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Acad, Dept Radiol,Inst Clin Sci, Gothenburg, Sweden.
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- Heck, Ansgar (author)
- Oslo Univ Hosp, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Pb 4950, N-0424 Oslo, Norway.
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- Godang, Kristin (author)
- Oslo Univ Hosp, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Pb 4950, N-0424 Oslo, Norway.
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- Mollerup, Charlotte (author)
- Copenhagen Univ Hosp, Ctr HOC, Clin Breast & Endocrine Surg, Rigshosp, Copenhagen, Denmark.
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- Baranowski, Marek (author)
- St Olavs Hosp, Trondheim, Norway.
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- Pernow, Ylva (author)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Endocrinol, Dept Mol Med & Surg, Stockholm, Sweden.
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- Aas, Turid (author)
- Haukeland Hosp, Dept Breast & Endocrine Surg, Bergen, Norway.
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- Hessman, Ola (author)
- Uppsala universitet,Endokrinkirurgi
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- Rosen, Thord (author)
- Sahlgrens Univ Hosp, Dept Med, Sect Endocrinol Diabet & Metab, Gothenburg, Sweden.
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- Nordenstrom, Jorgen (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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- Jansson, Svante, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Acad, Dept Surg,Inst Clin Sci, Gothenburg, Sweden.
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- Hellström, Mikael, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Acad, Dept Radiol,Inst Clin Sci, Gothenburg, Sweden.
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- Bollerslev, Jens (author)
- Oslo Univ Hosp, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Pb 4950, N-0424 Oslo, Norway.
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(creator_code:org_t)
- 2017-07-07
- 2017
- English.
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In: Journal of Bone and Mineral Research. - : Wiley. - 0884-0431 .- 1523-4681. ; 32:9, s. 1907-1914
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Abstract
Subject headings
Close
- Mild primary hyperparathyroidism (PHPT) is known to affect the skeleton, even though patients usually are asymptomatic. Treatment strategies have been widely discussed. However, long-term randomized studies comparing parathyroidectomy to observation are lacking. The objective was to study the effect of parathyroidectomy (PTX) compared with observation (OBS) on bone mineral density (BMD) in g/cm(2) and T-scores and on biochemical markers of bone turnover (P1NP and CTX-1) in a prospective randomized controlled study of patients with mild PHPT after 5 years of follow-up. Of 191 patients with mild PHPT randomized to either PTX or OBS, 145 patients remained for analysis after 5 years (110 with validated DXA scans). A significant decrease in P1NP (p<0.001) and CTX-1 (p<0.001) was found in the PTX group only. A significant positive treatment effect of surgery compared with observation on BMD (g/cm(2)) was found for the lumbar spine (LS) (p = 0.011), the femoral neck (FN) (p<0.001), the ultradistal radius (UDR) (p = 0.042), and for the total body (TB) (p<0.001) but not for the radius 33% (Rad33), where BMD decreased significantly also in the PTX group (p = 0.012). However, compared with baseline values, there was no significant BMD increase in the PTX group, except for the lumbar spine. In the OBS group, there was a significant decrease in BMD (g/cm(2)) for all compartments (FN, p<0.001; Rad33, p = 0.001; UDR, p = 0.006; TB, p<0.001) with the exception of the LS, whereBMDwas stable. In conclusion, parathyroidectomy improves BMD and observation leads to a small but statistically significant decrease in BMD after 5 years. Thus, bone health appears to be a clinical concern with long-term observation in patients with mild PHPT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- PARATHYROID-RELATED DISORDERS
- PTH
- DXA
- BIOCHEMICAL MARKERS OF BONE TURNOVER
- CLINICAL TRIALS
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lundstam, Karoli ...
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Heck, Ansgar
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Godang, Kristin
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Mollerup, Charlo ...
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Baranowski, Mare ...
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Pernow, Ylva
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Aas, Turid
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Hessman, Ola
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Rosen, Thord
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Nordenstrom, Jor ...
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Jansson, Svante, ...
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Hellström, Mikae ...
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Bollerslev, Jens
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Journal of Bone ...
- By the university
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Uppsala University
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Karolinska Institutet
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University of Gothenburg